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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 8 - 20 (13page)
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Staphylococcus aureus, a Gram-positive pathogen, can cause severe inflammation in humans, leading to various life-threatening diseases. The lipoprotein is a major virulence factor in S. aureus-induced infectious diseases and is responsible for excessive inflammatory mediators such as nitric oxide (NO). Short-chain fatty acids (SCFAs) including butyrate, propionate, and acetate are microbial metabolites in the gut that are known to have anti-inflammatory effects in the host. In this study, we investigated the effects of SCFAs on S. aureus lipoprotein (Sa.LPP)-induced NO production in mouse macrophages. Butyrate and propionate, but not acetate, inhibited Sa.LPP-induced production of NO in RAW 264.7 cells and bone marrowderived macrophages. Butyrate and propionate inhibited Sa.LPP-induced expression of inducible NO synthase (iNOS). However, acetate did not show such effects under the same conditions. Furthermore, butyrate and propionate, but not acetate, inhibited Sa.LPP-induced activation of NF-κB, expression of IFN-β, and phosphorylation of STAT1, which are essential for inducing transcription of iNOS in macrophages. In addition, butyrate and propionate induced histone acetylation at lysine residues in the presence of Sa.LPP in RAW 264.7 cells. Moreover, Sa.LPP-induced NO production was decreased by histone deacetylase (HDAC) inhibitors. Collectively, these results suggest that butyrate and propionate ameliorate the inflammatory responses caused by S. aureus through the inhibition of NF-κB, IFN-β/STAT1, and HDAC, resulting in attenuated NO production in macrophages.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (49)
참고문헌 신청
Bettenworth D / 2013 / Crohn's disease complicated by intestinal infection with methicillin-resistant Staphylococcus aureus / World J Gastroenterol 19:4418~4421
Lowy FD / 1998 / Staphylococcus aureus infections / N Engl J Med 339:520~532
Kawai T / 2011 / Toll-like receptors and their crosstalk with other innate receptors in infection and immunity / Immunity 34:637~650
Han SH / 2006 / Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2 / J Immunol 176:573~579
Noh SY / 2015 / Lipoteichoic acid from Lactobacillus plantarum inhibits Pam2CSK4-induced IL-8 production in human intestinal epithelial cells / Mol Immunol 64:183~189
Lowy FD / 1998 / Staphylococcus aureus infections / N Engl J Med 339:520~532
Kawai T / 2011 / Toll-like receptors and their crosstalk with other innate receptors in infection and immunity / Immunity 34:637~650
Han SH / 2006 / Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2 / J Immunol 176:573~579
Noh SY / 2015 / Lipoteichoic acid from Lactobacillus plantarum inhibits Pam2CSK4-induced IL-8 production in human intestinal epithelial cells / Mol Immunol 64:183~189
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UCI(KEPA) : I410-ECN-0101-2019-517-000786755