Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic

Amir Mohammad Kazemifar; Ali Akbar Shafikhani; Hossein Mozhdehipanah; Shali Khamesi; Maryam Arami

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자료유형: 학술저널

저자정보: Amir Mohammad Kazemifar (Qazvin University of Medical Sciences) Ali Akbar Shafikhani (Shahid Beheshti University of Medical Sciences) Hossein Mozhdehipanah (Qazvin University of Medical Sciences) Shali Khamesi (Qazvin University of Medical Sciences) Maryam Arami (Qazvin University of Medical Sciences)

저널정보: 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.35 No.2

발행연도: 2020.6

수록면: 13 - 18 (6page)

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Evidence suggests that the relationship between arsenic metabolism and diseases, including metabolic syndrome, is complex. The aim of this study was to evaluate the different types of arsenic methylation and its association with metabolic syndrome in an arsenic endemic area. A cross-sectional study was conducted on 132 subjects from Shahid-Abad Village, Qazvin province, Iran (arsenic endemic area). Demographic characteristics, metabolic syndrome, and urinary arsenic species, including iAs (inorganic arsenic), MMA (monomethylarsonic acid), and DMA (dimethylarsinic acid) were measured for all patients and their relationship was analyzed by appropriate statistical methods. In this study, 34.5% of the participants had metabolic syndrome. The decrease in %MMA, increase in %DMA and increase in secondary methylation index (DMA/MMA) were associated with increased risk of metabolic syndrome (p<0.05). We did not find any association between the incidence of metabolic syndrome with primary methylation index (MMA/iAs) and %iAs (p>0.05). This study showed that the prevalence of metabolic syndrome was significantly higher in people with metabolic syndrome than in the general population. A closer examination revealed that the secondary methylation index is related to the metabolic syndrome and its components. Given the higher prevalence of cardiovascular disease and diabetes in patients with metabolic syndrome, it is necessary to change the pathogenesis of the disease using comprehensive management methods for decreasing patient complications.

#arsenic toxicity #metabolism #diabetes #glucose #metabolic syndrome

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