지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 39 - 45 (7page)
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초록· 키워드
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Purpose: High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone density compared to the general population.
Methods: Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An age-matched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups.
Results: In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%.
Conclusion: Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer age-matched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required.
Methods: Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An age-matched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups.
Results: In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%.
Conclusion: Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer age-matched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Bruyere O / 2017 / Skeletal health in breast cancer survivors / Maturitas 105:78~82
Peppone LJ / 2014 / Bone health issues in breast cancer survivors : a Medicare Current Beneficiary Survey(MCBS)study / Support Care Cancer 22:245~251
Hadji P / 2009 / The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer / Eur J Cancer 45:3205~3212
Hadji P / 2009 / Aromatase inhibitor-associated bone loss in breast cancer patients is distinct from postmenopausal osteoporosis / Crit Rev Oncol Hematol 69:73~82
Body JJ / 2011 / Increased fracture rate in women with breast cancer : a review of the hidden risk / BMC Cancer 11:384
Peppone LJ / 2014 / Bone health issues in breast cancer survivors : a Medicare Current Beneficiary Survey(MCBS)study / Support Care Cancer 22:245~251
Hadji P / 2009 / The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer / Eur J Cancer 45:3205~3212
Hadji P / 2009 / Aromatase inhibitor-associated bone loss in breast cancer patients is distinct from postmenopausal osteoporosis / Crit Rev Oncol Hematol 69:73~82
Body JJ / 2011 / Increased fracture rate in women with breast cancer : a review of the hidden risk / BMC Cancer 11:384
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UCI(KEPA) : I410-ECN-0101-2020-514-000882463