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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.7
- 수록면
- 580 - 592 (13page)
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초록· 키워드
오류제보하기
Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people’s physical vitality and is also a noneorgan-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms.
Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng.
Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cellemediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2.
Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.
Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng.
Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cellemediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2.
Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (45)
참고문헌 신청
Belbasis L / 2016 / Non-genetic risk factors for cutaneous melanoma and keratinocyte skin cancers : an umbrella review of meta-analyses / J Dermatol Sci 84:330~339
Whiteman DC / 2016 / The growing burden of invasive melanoma : projections of incidence rates and numbers of new cases in six susceptible populations through 2031 / J Invest Dermatol 136:1161~1171
Mohan SV / 2015 / Management of cutaneous and extracutaneous side effects of smoothened inhibitor therapy for advanced basal cell carcinoma / Clin Cancer Res 21:2677~2683
Christensen SR / 2018 / Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas / F1000Res 7
Unsal AA / 2018 / Cutaneous squamous cell carcinoma of the lip : a population-based analysis / Laryngoscope 128:84~90
Whiteman DC / 2016 / The growing burden of invasive melanoma : projections of incidence rates and numbers of new cases in six susceptible populations through 2031 / J Invest Dermatol 136:1161~1171
Mohan SV / 2015 / Management of cutaneous and extracutaneous side effects of smoothened inhibitor therapy for advanced basal cell carcinoma / Clin Cancer Res 21:2677~2683
Christensen SR / 2018 / Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas / F1000Res 7
Unsal AA / 2018 / Cutaneous squamous cell carcinoma of the lip : a population-based analysis / Laryngoscope 128:84~90
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UCI(KEPA) : I410-ECN-0101-2020-524-000843260