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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 738 - 746 (9page)
이용수
초록· 키워드
오류제보하기
Background: Red ginseng contains components, including microelements, vitamins, essential oils, and fatty acids, that can be used in skincare to delay the aging process. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis.
Methods: Human dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using atomic force microscopy. Cytoskeletal changes and mRNA expression of biomarkers of aging, including that of procollagens I and VII, elastin, and fibrillin-1, were investigated. Collagen in a human skin equivalent treated with red ginseng was visualized via hematoxylin and eosin staining, scanning electron microscopy, and atomic force microscopy.
Results and conclusion: The stiffness of fibroblasts was significantly reduced by treatment with red ginseng concentrations of ≥ 0.8 mg/mL. The ratio of F-actin to G-actin decreased after treatment, which corresponded to a change in fibroblast stiffness. The storage modulus (G") and loss modulus (G") of the skin equivalent were both lowered by red ginseng treatment. This result indicates that the viscoelasticity of the skin equivalent can be restored by red ginseng treatment.
Methods: Human dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using atomic force microscopy. Cytoskeletal changes and mRNA expression of biomarkers of aging, including that of procollagens I and VII, elastin, and fibrillin-1, were investigated. Collagen in a human skin equivalent treated with red ginseng was visualized via hematoxylin and eosin staining, scanning electron microscopy, and atomic force microscopy.
Results and conclusion: The stiffness of fibroblasts was significantly reduced by treatment with red ginseng concentrations of ≥ 0.8 mg/mL. The ratio of F-actin to G-actin decreased after treatment, which corresponded to a change in fibroblast stiffness. The storage modulus (G") and loss modulus (G") of the skin equivalent were both lowered by red ginseng treatment. This result indicates that the viscoelasticity of the skin equivalent can be restored by red ginseng treatment.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusions
References
참고문헌 (36)
참고문헌 신청
Ganceviciene R / 2012 / Skin anti-aging strategies / Dermatoendocrinol 4:308~319
김주원 / 2017 / Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation / Journal of Ginseng Research 41(3):277~283
Gunin AG / 2015 / Age-related changes of blood vessels in the human dermis / Adv Gerontol 5:65~71
Sator PG / 2006 / Skin treatments and dermatological procedures to promote youthful skin / Clin Interv Aging 1:51~56
Diridollou S / 2001 / Skin ageing : changes of physical properties of human skin in vivo / Int J Cosmet Sci 23:353~362
김주원 / 2017 / Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation / Journal of Ginseng Research 41(3):277~283
Gunin AG / 2015 / Age-related changes of blood vessels in the human dermis / Adv Gerontol 5:65~71
Sator PG / 2006 / Skin treatments and dermatological procedures to promote youthful skin / Clin Interv Aging 1:51~56
Diridollou S / 2001 / Skin ageing : changes of physical properties of human skin in vivo / Int J Cosmet Sci 23:353~362
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UCI(KEPA) : I410-ECN-0101-2020-524-001312979