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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 665 - 670 (6page)
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초록· 키워드
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Nucleotide-binding oligomerization domain protein 2 (NOD2), an intracellular pattern recognition receptor, plays important roles in inflammation and cell death. Previously, we have shown that NOD2 is expressed in vascular smooth muscle cells (VSMCs) and that NOD2 deficiency promotes VSMC proliferation, migration, and neointimal formation after vascular injury. However, its role in endoplasmic reticulum (ER) stress-induced cell death in VSMCs remains unclear. Thus, the objective of this study was to evaluate ER stress-induced viability of mouse primary VSMCs. NOD2 deficiency increased ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) in VSMCs in the presence of tunicamycin (TM), an ER stress inducer. In contrast, ER stress-induced cell death and expression levels of apoptosis mediators (cleaved caspase-3, Bax, and Bak) were decreased in NOD2-overexpressed VSMCs. We found that the IRE-1-XBP1 pathway, one of unfolded protein response branches, was decreased in NOD2-deficient VSMCs and reversed in NOD2-overexpressed VSMCs in the presence of TM. Furthermore, NOD2 deficiency reduced the expression of XBP1 target genes such as GRP78, PDI-1, and Herpud1, thus improving cell survival. Taken together, these data suggest that the induction of ER stress through NOD2 expression can protect against TM-induced cell death in VSMCs. These results may contribute to a new paradigm in vascular homeostasis.
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참고문헌 (19)
참고문헌 신청
Binet F / 2015 / ER Stress and Angiogenesis / Cell Metab 22:560~575
Scull CM / 2011 / Mechanisms of ER stressinduced apoptosis in atherosclerosis / Arterioscler Thromb Vasc Biol 31:2792~2797
Jiang D / 2015 / Targeting the IRE1 α-XBP1 branch of the unfolded protein response in human diseases / Semin Cancer Biol 33:48~56
Li H / 2010 / Mammalian endoplasmic reticulum stress sensor IRE1signals by dynamic clustering / Proc Natl Acad Sci U S A 107:16113~16118
Hirota M / 2006 / Quantitative measurement of spliced XBP1 mRNA as an indicator of endoplasmic reticulum stress / J Toxicol Sci 31:149~156
Scull CM / 2011 / Mechanisms of ER stressinduced apoptosis in atherosclerosis / Arterioscler Thromb Vasc Biol 31:2792~2797
Jiang D / 2015 / Targeting the IRE1 α-XBP1 branch of the unfolded protein response in human diseases / Semin Cancer Biol 33:48~56
Li H / 2010 / Mammalian endoplasmic reticulum stress sensor IRE1signals by dynamic clustering / Proc Natl Acad Sci U S A 107:16113~16118
Hirota M / 2006 / Quantitative measurement of spliced XBP1 mRNA as an indicator of endoplasmic reticulum stress / J Toxicol Sci 31:149~156
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