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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 82 - 87 (6page)
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Circular RNAs (circRNAs), one kind of non-coding RNA, have been reported as critical regulators for modulating gene expression in cancer. In this study, microarray analysis was used to screen circRNA expression profiles of bladder cancer (BC) 5637 cells, T24 cells and normal control SV-HUC-1 cells. The data from the microarray showed that hsa_circ_0075828 (named circCASC15) was most highly expressed in 5637 and T24 cells. circCASC15 was highly expressed in BC tissues and cells. Overexpression of circCASC15 was closely associated with BC tumor stage and promoted cell proliferation significantly in vitro and in vivo. Mechanistically, circCASC15 could act as miR-1224-5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. In short, circCASC15 promotes cell proliferation in BC, which might be a new molecular target for BC diagnosis and therapy.
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참고문헌 (27)
참고문헌 신청
Siegel RL / 2017 / Cancer Statistics, 2017 / CA Cancer J Clin 67:7~30
Cote RJ / 1998 / Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53 / Cancer Res 58:1090~1094
Cambier S / 2016 / EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non-Muscle-invasive Stage Ta-T1 Urothelial Bladder Cancer Patients Treated with 1-3 Years of Maintenance Bacillus Calmette-Guerin / Eur Urol 69:60~69
Wu X / 2016 / BRD4 Regulates EZH2Transcription through Upregulation of C-MYC and Represents a Novel Therapeutic Target in Bladder Cancer / Mol Cancer Ther 15:1029~1042
Wilusz JE / 2013 / Molecular biology. A circuitous route to noncoding RNA / Science 340:440~441
Cote RJ / 1998 / Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53 / Cancer Res 58:1090~1094
Cambier S / 2016 / EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non-Muscle-invasive Stage Ta-T1 Urothelial Bladder Cancer Patients Treated with 1-3 Years of Maintenance Bacillus Calmette-Guerin / Eur Urol 69:60~69
Wu X / 2016 / BRD4 Regulates EZH2Transcription through Upregulation of C-MYC and Represents a Novel Therapeutic Target in Bladder Cancer / Mol Cancer Ther 15:1029~1042
Wilusz JE / 2013 / Molecular biology. A circuitous route to noncoding RNA / Science 340:440~441
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