지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 191 - 201 (11page)
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초록· 키워드
오류제보하기
Boswellia Carterii, a well-known plant species used in Korean medicine, is particularly effective in anti-cancer and inflammatory diseases. Its gum created from white resin is known to have therapeutic effects. However, the study on the anti-cancer pathway is very limited in human pancreatic cancer cells. thus, we investigated the changes in overall oncologic gene expression when treated BC in AsPC-1 cells. In this paper, we aimed to see how BC can be used to decrease cell viability with full explanation of gene expression in AsPC-1. We used MTT, microarray, and qRT-PCR to confirm our thesis. Results showed that BC inhibited cell viability in AsPC-1 by more than two-fold, which implies that BC has cell cytotoxic effects. Also, BC induced early and late apoptosis when treated for 24h on the pancreatic cancer cells. Differentially expressed genes were analyzed by microarray for demonstrated apoptotic effects at the mRNA level. The number of genes were related to participation in the oxidation-reduction process or signaling pathways. The signal pathway was verified by western blotting mainly STAT3 but also JAK, Src, ERK, JNK, and Akt. The results prove that stress signaling such as cytokines were regulated by BC stimulation. Therefore, our findings support the show that differentially expressed genes in BC-treated represent anti- cancer effects in pancreatic cancer and this has the potential for further understanding of the entire mechanism of cancer and its treatment.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Siegel, R. L. / 2018 / Cancer statistics / Ca-Cancer J. Clin 68:7~30
Kamisawa, T. / 2016 / Pancreatic cancer / Lancet 388:73~85
Aier, I. / 2019 / A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer / Cancer Epidemiol 58:104~110
Park, B. / 2011 / Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets / PLoS One 6:e26943
Suhail, M. M. / 2011 / Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells / BMC Complementary Altern. Med 11:129
Kamisawa, T. / 2016 / Pancreatic cancer / Lancet 388:73~85
Aier, I. / 2019 / A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer / Cancer Epidemiol 58:104~110
Park, B. / 2011 / Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets / PLoS One 6:e26943
Suhail, M. M. / 2011 / Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells / BMC Complementary Altern. Med 11:129
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