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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 278 - 283 (6page)
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초록· 키워드
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Muscle fibers are generally formed as multinucleated fibers that are differentiated from myoblasts. Several reports have identified transcription factors and proteins involved in the process of muscle differentiation, but the roles of microRNAs (miRNAs) in myogenesis remain unclear. Here, comparative analysis of the miRNA expression profiles in mouse myoblasts and gastrocnemius (GA) muscle uncovered miR-3074-3p as a novel miRNA showing markedly reduced expression in fully differentiated adult skeletal muscle. Interestingly, elevating miR-3074-3p promoted myogenesis in C2C12 cells, primary myoblasts, and HSMMs, resulting in increased mRNA expression of myogenic makers such as Myog and MyHC. Using a target prediction program, we identified Caveolin-1 (Cav1) as a target mRNA of miR-3074-3p and verified that miR-3074-3p directly interacts with the 3’ untranslated region (UTR) of Cav1 mRNA. Consistent with the findings in miR-3074-3p-overexpressing myoblasts, knockdown of Cav1 promoted myogenesis in C2C12 cells and HSMMs. Taken together, our results suggest that miR-3074-3p acts a positive regulator of myogenic differentiation by targeting Cav1.
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참고문헌 (38)
참고문헌 신청
Mauro A / 1961 / Satellite cell of skeletal muscle fibers / J Biophys Biochem Cytol 9:493~495
Relaix F / 2012 / Satellite cells are essential for skeletal muscle regeneration : the cell on the edge returns centre stage / Development 139:2845~2856
Bernet JD / 2014 / p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice / Nat Med 20:265~271
He WA / 2013 / NF-kappaBmediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia / J Clin Invest 123:4821~4835
Blau HM / 1983 / Defective myoblasts identified in Duchenne muscular dystrophy / Proc Natl Acad Sci U S A 80:4856~4860
Relaix F / 2012 / Satellite cells are essential for skeletal muscle regeneration : the cell on the edge returns centre stage / Development 139:2845~2856
Bernet JD / 2014 / p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice / Nat Med 20:265~271
He WA / 2013 / NF-kappaBmediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia / J Clin Invest 123:4821~4835
Blau HM / 1983 / Defective myoblasts identified in Duchenne muscular dystrophy / Proc Natl Acad Sci U S A 80:4856~4860
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