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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 747 - 754 (8page)
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초록· 키워드
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The incidence of atherosclerosis is higher among patients with several autoimmune diseases such as psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). It is well documented that innate immune cells including macrophages and dendritic cells sense lipid species such as saturated fatty acids and oxidized low-density lipoprotein and produce pro-inflammatory cytokines and chemokines. However, whether a hyperlipidemic environment also impacts autoimmune T cell responses has been unclear. Among CD4+ T cells, Th17 and follicular helper T (Tfh) cells are known to play pathogenic roles in the development of hyperlipidemiaassociated autoimmune diseases. This review gives an overview of the cellular and molecular mechanisms by which dysregulated lipid metabolism impacts the pathogenesis of autoimmune diseases, with specific emphasis on Th17 and Tfh cells.
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참고문헌 (73)
참고문헌 신청
A-Gonzalez, N. / 2009 / Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR / Immunity 31:245~258
Ait-Oufella, H. / 2006 / Natural regulatory T cells control the development of atherosclerosis in mice / Nat. Med 12:178~180
Aktas, O. / 2003 / Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1cells through atorvastatin / J. Exp. Med 197:725~733
Anaya, J. M. / 2012 / Common mechanisms of autoimmune diseases(the autoimmune tautology) / Autoimmun. Rev 11:781~784
Bao, Y. K. / 2019 / High prevalence of comorbid autoimmune diseases in adults with type 1 diabetes from the HealthFacts database / J. Diabetes 11:273~279
Ait-Oufella, H. / 2006 / Natural regulatory T cells control the development of atherosclerosis in mice / Nat. Med 12:178~180
Aktas, O. / 2003 / Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1cells through atorvastatin / J. Exp. Med 197:725~733
Anaya, J. M. / 2012 / Common mechanisms of autoimmune diseases(the autoimmune tautology) / Autoimmun. Rev 11:781~784
Bao, Y. K. / 2019 / High prevalence of comorbid autoimmune diseases in adults with type 1 diabetes from the HealthFacts database / J. Diabetes 11:273~279
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