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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 360 - 372 (13page)
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초록· 키워드
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The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) (‘bridging collaterals’) was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Abdi, A. / 2015 / Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus / J. Neurosci 35:6667~6688
Albin, R. L. / 1989 / The functional anatomy of basal ganglia disorders / Trends Neurosci 12:366~375
Alexander, G. E. / 1986 / Parallel organization of functionally segregated circuits linking basal ganglia and cortex / Annu. Rev. Neurosci 9:357~381
Bateup, H. S. / 2010 / Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors / Proc. Natl. Acad. Sci. U. S. A 107:14845~14850
Bhatia, K. P. / 1994 / The behavioural and motor consequences of focal lesions of the basal ganglia in man / Brain 117:859~876
Albin, R. L. / 1989 / The functional anatomy of basal ganglia disorders / Trends Neurosci 12:366~375
Alexander, G. E. / 1986 / Parallel organization of functionally segregated circuits linking basal ganglia and cortex / Annu. Rev. Neurosci 9:357~381
Bateup, H. S. / 2010 / Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors / Proc. Natl. Acad. Sci. U. S. A 107:14845~14850
Bhatia, K. P. / 1994 / The behavioural and motor consequences of focal lesions of the basal ganglia in man / Brain 117:859~876
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