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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 540 - 547 (8page)
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Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting approximately 5% of children. However, the neural mechanisms underlying its development and treatment are yet to be elucidated. In this study, we report that an ADHD mouse model, which harbors a deletion in the Git1 locus, exhibits severe astrocytosis in the globus pallidus (GP) and thalamic reticular nucleus (TRN), which send modulatory GABAergic inputs to the thalamus. A moderate level of astrocytosis was displayed in other regions of the basal ganglia pathway, including the ventrobasal thalamus and cortex, but not in other brain regions, such as the caudate putamen, basolateral amygdala, and hippocampal CA1.
This basal ganglia circuit-selective astrocytosis was detected in both in adult (2-3 months old) and juvenile (4 weeks old) Git1?/? mice, suggesting a developmental origin.
Astrocytes play an active role in the developing synaptic circuit; therefore, we performed an immunohistochemical analysis of synaptic markers. We detected increased and decreased levels of GABA and parvalbumin (PV), respectively, in the GP. This suggests that astrocytosis may alter synaptic transmission in the basal ganglia. Intriguingly, increased GABA expression colocalized with the astrocyte marker, GFAP, indicative of an astrocytic origin. Collectively, these results suggest that defects in basal ganglia circuitry, leading to impaired inhibitory modulation of the thalamus, are neural correlates for the ADHD-associated behavioral manifestations in Git1?/? mice.
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참고문헌 (49)
참고문헌 신청
Anaya-Martinez, V. / 2006 / Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus : implications for abnormal motor behavior / Neuroscience 143:477~486
Araque, A. / 1998 / Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons / Eur. J. Neurosci 10:2129~2142
Aylward, E. H. / 1996 / Basal ganglia volumes in children with attention-deficit hyperactivity disorder / J. Child Neurol 11:112~115
Biederman, J. / 2005 / Attention-deficit/hyperactivity disorder : a selective overview / Biol. Psychiatry 57:1215~1220
Castellanos, F. X. / 1996 / Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder / Arch. Gen. Psychiatry 53:607~616
Araque, A. / 1998 / Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons / Eur. J. Neurosci 10:2129~2142
Aylward, E. H. / 1996 / Basal ganglia volumes in children with attention-deficit hyperactivity disorder / J. Child Neurol 11:112~115
Biederman, J. / 2005 / Attention-deficit/hyperactivity disorder : a selective overview / Biol. Psychiatry 57:1215~1220
Castellanos, F. X. / 1996 / Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder / Arch. Gen. Psychiatry 53:607~616
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