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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 408 - 418 (11page)
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초록· 키워드
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The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)—characterized by electrical remodeling—is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated with increased risk of cardiovascular disorders, including syncope, heart failure, and atrial arrhythmias, particularly atrial fibrillation. One of the histological SND hallmarks is degenerative atrial remodeling that is associated with conduction abnormalities and increased right atrial refractoriness. Although SND is frequently accompanied by increased fibrosis in the right atrium (RA), its molecular basis still remains elusive. Therefore, we investigated whether SND can induce significant molecular changes that account for the structural remodeling of RA. Towards this, we employed a rabbit model of experimental SND, and then compared the genome-wide RNA expression profiles in RA between SND-induced rabbits and sham-operated controls to identify the differentially expressed transcripts. The accompanying gene enrichment analysis revealed extensive pro-fibrotic changes within 7 days after the SN ablation, including activation of transforming growth factor-β (TGF-β) signaling and alterations in the levels of extracellular matrix components and their regulators. Importantly, our findings suggest that periostin, a matricellular factor that regulates the development of cardiac tissue, might play a key role in mediating TGF-β-signaling-induced aberrant atrial remodeling. In conclusion, the present study provides valuable information regarding the molecular signatures underlying SND-induced atrial remodeling, and indicates that periostin can be potentially used in the diagnosis of fibroproliferative cardiac dysfunctions.
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참고문헌 (63)
참고문헌 신청
Abe, K. / 2014 / Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics / Circ. Arrhythm. Electrophysiol 7:511~517
Alonso, A. / 2014 / Association of sick sinus syndrome with incident cardiovascular disease and mortality : the atherosclerosis risk in communities study and cardiovascular health study / PLoS One 9:e109662
Amasyali, B. / 2014 / Sinus node dysfunction and atrial fibrillation: which one dominates? / Int. J. Cardiol. 175:379~380
Andersen, H. R. / 1997 / Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome / Lancet 350:1210~1216
Assayag, P. / 1997 / Compensated cardiac hypertrophy:arrhythmogenicity and the new myocardial phenotype. I. fibrosis / Cardiovasc. Res. 34:439~444
Alonso, A. / 2014 / Association of sick sinus syndrome with incident cardiovascular disease and mortality : the atherosclerosis risk in communities study and cardiovascular health study / PLoS One 9:e109662
Amasyali, B. / 2014 / Sinus node dysfunction and atrial fibrillation: which one dominates? / Int. J. Cardiol. 175:379~380
Andersen, H. R. / 1997 / Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome / Lancet 350:1210~1216
Assayag, P. / 1997 / Compensated cardiac hypertrophy:arrhythmogenicity and the new myocardial phenotype. I. fibrosis / Cardiovasc. Res. 34:439~444
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