지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 353 - 361 (9page)
- DOI
- 10.14348/molcells.2022.0019
이용수
초록· 키워드
오류제보하기
Chronic rhinosinusitis (CRS) is a multifactorial, heterogeneous disease characterized by persistent inflammation of the sinonasal mucosa and tissue remodeling, which can include basal/progenitor cell hyperplasia, goblet cell hyperplasia, squamous cell metaplasia, loss or dysfunction of ciliated cells, and increased matrix deposition. Repeated injuries can stimulate airway epithelial cells to produce inflammatory mediators that activate epithelial cells, immune cells, or the epithelial–mesenchymal trophic unit. This persistent inflammation can consequently induce aberrant tissue remodeling. However, the molecular mechanisms driving disease within the different molecular CRS subtypes remain inadequately characterized. Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. Therefore, these precursor proteins require post-translational cleavage by proprotein convertases (PCs) to become fully functional. In this review, we summarize the roles of PCs in CRS-associated tissue remodeling and discuss the therapeutic potential of targeting PCs for CRS treatment.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
노후 공동주택 리모델링 사업모델별 사업범위 및 사업프로세스 연구
한국주거학회논문집
2018 .12
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases
Molecules and Cells
2023 .02
-
Characterization of Control Reference Standards(CRS)
한국분석과학회 학술대회
2015 .11
-
Single-Cell Molecular Barcoding to Decode Multimodal Information Defining Cell States
Molecules and Cells
2023 .02
-
공동주택 리모델링 수요 예측을 통한 정책방향 설정
한국주거학회 학술대회논문집
2016 .04
-
Cytotoxicity and inhibition cell growth assessment in lung epithelial cell A549 of cinnamaldehyde
한국분석과학회 학술대회
2017 .11
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells
Nutrition Research and Practice
2023 .08
-
IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells
Nutrition Research and Practice
2023 .08
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
Brief guide to senescence assays using cultured mammalian cells
Molecules and Cells
2024 .01
-
서울과 베이징의 PM2.5 유기성분의 특성 파악 및 세포 노출을 통한 독성 평가
한국대기환경학회 학술대회논문집
2021 .10
-
공동주택 리모델링 성능등급 개발방향 설정
한국주거학회논문집
2016 .08
-
The Role of Extracellular Vesicles in Senescence
Molecules and Cells
2022 .09
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
-
그린리모델링 기숙사의 물리적환경 변화와 거주자평가
한국주거학회논문집
2017 .02
-
Adipose tissue macrophage heterogeneity in the single-cell genomics era
Molecules and Cells
2024 .01
-
Cell Death Inhibition Effect of Antioxidant Activity by 630 and 850 nm LEDs in RAW264.7 Cells
Current Optics and Photonics
2024 .10
-
그린리모델링 기숙사의 물리적환경 변화와 거주자평가
한국주거학회 학술대회논문집
2015 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0