지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 419 - 430 (12page)
이용수
초록· 키워드
오류제보하기
The liver is an important organ in the regulation of glucose and lipid metabolism. It is responsible for systemic energy homeostasis. When energy need exceeds the storage capacity in the liver, fatty acids are shunted into nonoxidative sphingolipid biosynthesis, which increases the level of cellular ceramides. Accumulation of ceramides alters substrate utilization from glucose to lipids, activates triglyceride storage, and results in the development of both insulin resistance and hepatosteatosis, increasing the likelihood of major metabolic diseases. Another sphingolipid metabolite, sphingosine 1-phosphate (S1P) is a bioactive signaling molecule that acts via S1P-specific G protein coupled receptors. It regulates many cellular and physiological events. Since an increase in plasma S1P is associated with obesity, it seems reasonable that recent studies have provided evidence that S1P is linked to lipid pathophysiology, including hepatosteatosis and fibrosis. Herein, we review recent findings on ceramides and S1P in obesity-mediated liver diseases and the therapeutic potential of these sphingolipid metabolites.
목차
등록된 정보가 없습니다.
참고문헌 (117)
참고문헌 신청
Aerts, J. M. / 2007 / Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity / Diabetes 56:1341~1349
Al Fadel, F. / 2016 / Involvement of sphingosine 1-phosphate in palmitate-induced non-alcoholic fatty liver disease / Cell. Physiol. Biochem 40:1637~1645
Barr, E. L. / 2010 / HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population : the Australian Diabetes, Obesity and Lifestyle Study(AusDiab)study / Diabetologia 53:79~88
Bashiardes, S. / 2016 / Nonalcoholic fatty liver and the gut microbiota / Mol. Metab 5:782~794
Bataller, R. / 2005 / Liver fibrosis / J. Clin. Invest 115:209~218
Al Fadel, F. / 2016 / Involvement of sphingosine 1-phosphate in palmitate-induced non-alcoholic fatty liver disease / Cell. Physiol. Biochem 40:1637~1645
Barr, E. L. / 2010 / HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population : the Australian Diabetes, Obesity and Lifestyle Study(AusDiab)study / Diabetologia 53:79~88
Bashiardes, S. / 2016 / Nonalcoholic fatty liver and the gut microbiota / Mol. Metab 5:782~794
Bataller, R. / 2005 / Liver fibrosis / J. Clin. Invest 115:209~218
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Metabolic Engineering of Sphingolipid Biosynthesis Pathway in Yarrowia lipolytica for Cell Surface-associated Production of Sphinganine, Sphingosine, and Human-type Ceramide
한국미생물학회 학술대회논문집
2022 .10
-
Optimization of Ceramide Analysis Method Using LC-MS in Cosmetics
Mass Spectrometry Letters
2024 .03
-
LC-MS/MS analysis of ceramide in Chronic kidney disease (CKD) model induced by adenine
한국분석과학회 학술대회
2020 .06
-
A rapid and sensitive quantification method of sphingosine and sphingosine-1-phosphate in asthmatic rat serum using UPLC-ESI-MS/MS
한국분석과학회 학술대회
2020 .11
-
LC-MS/MS analysis of ceramide accumulation in atopic dermatitis model mice induced by MC903
한국분석과학회 학술대회
2019 .11
-
Optimization of ceramide characterization method using ESI-Q-TOF/MS
한국분석과학회 학술대회
2023 .05
-
Pf 543 and its Analogs Differently Accumulates Ceramide Groups in HaCaT Cell
한국분석과학회 학술대회
2019 .05
-
Pf 543 and its Analogs Differently Accumulates Ceramide Groups in HaCaT Cell
한국분석과학회 학술대회
2019 .05
-
Comparative LC-MS/MS profiling of sphingolipids in mouse tissues
한국분석과학회 학술대회
2023 .11
-
Bioinformatic Analysis of Sphingolipid Metabolism-related Genes for Prognostic Significance in Patients with Hepatocellular Carcinoma using The Cancer Genome Atlas Liver Cancer Cohort
Quantitative Bio-Science
2020 .05
-
Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease
Molecules and Cells
2019 .01
-
The Quantification of Total Ceramide in LLC-PK1 Cells by HPLC-FLD method
한국분석과학회 학술대회
2019 .05
-
Sphingolipids analysis by LC-MS/MS after treatment with xanthine oxidase inhibitors of nephrotoxicity induced by adenine
한국분석과학회 학술대회
2022 .05
-
Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD
Molecules and Cells
2024 .01
-
Sphingosine-1-phosphate lyase activity assay by HPLC-fluorescence detection
한국분석과학회 학술대회
2020 .11
-
Upregulation of Carbonyl Reductase 1 by Nrf2 as a Potential Therapeutic Intervention for Ischemia/ Reperfusion Injury during Liver Transplantation
Molecules and Cells
2019 .01
-
Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation
Nutrition Research and Practice
2017 .06
-
Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation
Nutrition Research and Practice
2017 .06
-
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes
Molecules and Cells
2015 .07
-
Effect of Negative Feedback Loop with Nrf1 and miR-378 of Nonalcoholic Fatty Liver Disease: A Mathematical Modeling Approach
East Asian Mathematical Journal
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0