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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 438 - 447 (10page)
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초록· 키워드
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The aim of this study was to explore the role of IL-6-miR-210 in the regulation of Tregs function and atrial fibrosis in atrial fibrillation (AF). The levels of interleukin (IL)-6 and IL-10 in AF patients were detected by using ELISA. Proportions of Treg cells were detected by fluorescence activated cell sorting analysis in AF patients. The expression of Foxp3, α-SMA, collagen I and collagen III were determined by western blot. The atrial mechanocytes were authenticated by vimentin immunostaining. The expression of miR-210 was performed by quantitative real-time polymerase chain reaction (qRT-PCR). TargetScan was used to predict potential targets of miR-210. The cardiomyocyte transverse sections in AF model group were observed by H&E staining. The myocardial filaments were observed by masson staining. The level of IL-6 was highly increased while the level of IL-10 (Tregs) was significantly decreased in AF patients as compared to normal control subjects, and IL-6 suppressed Tregs function and promoted the expression of α-SMA, collagen I and collagen III. Furthermore, miR-210 regulated Tregs function by targeting Foxp3, and IL-6 promoted expression of miR-210 via regulating hypoxia inducible factor-1α (HIF-1α). IL-6-miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting Foxp3.
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참고문헌 (33)
참고문헌 신청
Ai, F. / 2015 / Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway / Int. J. Clin. Exp. Pathol 8:12509~12516
Ashikaga, K. / 2006 / Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model / Eur. J. Pharmacol 536:148~153
Bao, B. / 2012 / Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment / PLoS One 7:e50165
Becker, W. / 2018 / miR-466a targeting of TGF-beta2 contributes to FoxP3(+)regulatory T cell differentiation in a murine model of allogeneic transplantation / Front. Immunol 9:688
Bodempudi, V. / 2014 / miR-210 promotes IPF fibroblast proliferation in response to hypoxia / Am. J. Physiol. Lung Cell. Mol. Physiol 307:L283~L294
Ashikaga, K. / 2006 / Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model / Eur. J. Pharmacol 536:148~153
Bao, B. / 2012 / Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment / PLoS One 7:e50165
Becker, W. / 2018 / miR-466a targeting of TGF-beta2 contributes to FoxP3(+)regulatory T cell differentiation in a murine model of allogeneic transplantation / Front. Immunol 9:688
Bodempudi, V. / 2014 / miR-210 promotes IPF fibroblast proliferation in response to hypoxia / Am. J. Physiol. Lung Cell. Mol. Physiol 307:L283~L294
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