지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제2호
- 발행연도
- 2020.1
- 수록면
- 306 - 312 (7page)
이용수
초록· 키워드
오류제보하기
Despite the importance of brown adipocytes as a therapeutic target for the prevention and treatment of obesity, the molecular mechanism underlying brown adipocyte differentiation is not fully understood. In particular, the role of post-translational modifications in brown adipocyte differentiation has not been extensively studied. Histidine phosphorylation is increasingly recognized an important process for protein post-translational modifications. In this study, we show that histidine phosphorylation patterns change during brown adipocyte differentiation. In addition, the expression level of protein histidine phosphatase 1 (PHPT1), a major mammalian phosphohistidine phosphatase, is reduced rapidly at the early phase of differentiation and recovers at the later phase. During white adipocyte differentiation of 3T3- L1 preadipocytes, however, the expression level of PHPT1 do not significantly change. Knockdown of PHPT1 promotes brown adipocyte differentiation, whereas ectopic expression of PHPT1 suppresses brown adipocyte differentiation. These results collectively suggest that histidine phosphorylation is closely linked to brown adipocyte differentiation and could be a therapeutic target for obesity and related metabolic disease
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Wang YC / 2014 / Protein posttranslational modifications and regulation of pluripotency in human stem cells / Cell Res 24:143~160
Son MJ / 2016 / Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation / Mol. Cell. Endocrinol 431:46~53
손민정 / 2016 / Methyltransferase and demethylase profiling studies during brown adipocyte differentiation / BMB Reports 49(7):388~393
Kee JM / 2013 / A panspecific antibody for direct detection of protein histidine phosphorylation / Nat. Chem. Biol 9:416~421
한미정 / 2017 / Comprehensive Analysis of Proteomic Differences between Escherichia coli K-12 and B Strains Using Multiplexed Isobaric Tandem Mass Tag (TMT) Labeling / Journal of Microbiology and Biotechnology 27(11):2028~2036
Son MJ / 2016 / Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation / Mol. Cell. Endocrinol 431:46~53
손민정 / 2016 / Methyltransferase and demethylase profiling studies during brown adipocyte differentiation / BMB Reports 49(7):388~393
Kee JM / 2013 / A panspecific antibody for direct detection of protein histidine phosphorylation / Nat. Chem. Biol 9:416~421
한미정 / 2017 / Comprehensive Analysis of Proteomic Differences between Escherichia coli K-12 and B Strains Using Multiplexed Isobaric Tandem Mass Tag (TMT) Labeling / Journal of Microbiology and Biotechnology 27(11):2028~2036
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Homeostatic balance of histone acetylation and deconstruction of repressive chromatin marker H3K9me3 during adipocyte differentiation of 3T3-L1 cells
Genes & Genomics
2018 .01
-
Inhibitory Effects and Molecular Mechanism of Adipocyte Differentiation by Rosae laevigata Fructus Ethanol Extracs
한국미생물·생명공학회지
2016 .01
-
Protein Tyrosine Phosphatase, Receptor Type B (PTPRB) Inhibits Brown Adipocyte Differentiation through Regulation of VEGFR2 Phosphorylation
Journal of Microbiology and Biotechnology
2019 .01
-
Soluble extract of soybean fermented with Aspergillus oryzae GB107 inhibits fat accumulation in cultured 3T3-L1 adipocytes
Nutrition Research and Practice
2015 .08
-
Soluble extract of soybean fermented with Aspergillus oryzae GB107 inhibits fat accumulation in cultured 3T3-L1 adipocytes
Nutrition Research and Practice
2015 .08
-
Psidium guajava L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cells
Nutrition Research and Practice
2021 .10
-
Psidium guajava L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cells
Nutrition Research and Practice
2021 .10
-
생강 성분인 (6)-Gingerol이 3T3-L1에서 지방세포 증식과 분화 과정에 미치는 영향
Journal of Nutrition and Health
2015 .08
-
Inhibition of Adipocyte Differentiation and Adipogenesis by Fermented Sea Tangle in Mouse 3T3-L1 Preadipocytes
한국미생물학회 학술대회논문집
2017 .04
-
The Anti-obesity Effect of Aureobasidium pullulans SM-2001 Extract (Polycan®) on 3T3-L1 Preadipocytes and Adipocytes
생명과학회지
2020 .10
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation
Molecules and Cells
2022 .12
-
Expression profile and estrogenic regulation of Amh during gonadal sex differentiation in northern snakehead (Channa argus)
Genes & Genomics
2020 .01
-
팔각회향 dichloromethane 분획물에 의한 지방세포 분화 억제 효과
생명과학회지
2019 .04
-
Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
Nutrition Research and Practice
2018 .12
-
Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells
Nutrition Research and Practice
2018 .12
-
Thermogenesis and cellular senescence of diabetic adipocytes in response to β-agonists and 18-carbon fatty acids
Journal of Nutrition and Health
2024 .08
-
Allium Hookeri Extract Enhances Glucose Uptake through GLUT4 Up-regulation in 3T3-L1 Cells
생명과학회지
2017 .03
-
Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
Nutrition Research and Practice
2021 .08
-
Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
Nutrition Research and Practice
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0