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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제1호
- 발행연도
- 2020.1
- 수록면
- 119 - 122 (4page)
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Morules, or morule-like features, can be identified in benign and malignant lesions in various organs. Morular features are unusual in pulmonary adenocarcinoma cases with only 26 cases reported to date. Here, we describe two cases of pulmonary adenocarcinoma with morule-like features in Korean women. One patient had a non-mucinous-type adenocarcinoma in situ and the other had an acinarpredominant adenocarcinoma with a micropapillary component. Both patients showed multiple intra-alveolar, nodular, whorled proliferative foci composed of atypical spindle cells with eosinophilic cytoplasm. Targeted next-generation sequencing was performed on DNA extracted from formalin-fixed paraffin-embedded samples of the tumors. Results showed unusual epidermal growth factor receptor (EGFR) mutations, which are associated with drug resistance to EGFR tyrosine kinase inhibitors, revealing the importance of identifying morule-like features in pulmonary adenocarcinoma and the need for additional study, since there are few reported cases.
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참고문헌 (10)
참고문헌 신청
Makishi S / 2006 / Morules and morule-like features associated with carcinomas in various organs : report with immunohistochemical and molecular studies / J Clin Pathol 59:95~100
Tsuta K / 2014 / Primary lung adenocarcinoma with morule-like components : a unique histologic hallmark of aggressive behavior and EGFR mutation / Lung Cancer 85:12~18
Fornelli A / 2003 / Bronchioloalveolar carcinoma with nodular("morule-like")features / Virchows Arch 442:407~408
Tajima S / 2015 / Transition between morule-like and solid components may occur in solid-predominant adenocarcinoma of the lung : report of 2 cases with EGFR and KRAS mutations / Int J Clin Exp Pathol 8:7475~7481
Moran CA / 2004 / Papillary lung carcinoma with prominent"morular"component / Am J Clin Pathol 122:106~109
Tsuta K / 2014 / Primary lung adenocarcinoma with morule-like components : a unique histologic hallmark of aggressive behavior and EGFR mutation / Lung Cancer 85:12~18
Fornelli A / 2003 / Bronchioloalveolar carcinoma with nodular("morule-like")features / Virchows Arch 442:407~408
Tajima S / 2015 / Transition between morule-like and solid components may occur in solid-predominant adenocarcinoma of the lung : report of 2 cases with EGFR and KRAS mutations / Int J Clin Exp Pathol 8:7475~7481
Moran CA / 2004 / Papillary lung carcinoma with prominent"morular"component / Am J Clin Pathol 122:106~109
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