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- 자료유형
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- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제1호
- 발행연도
- 2020.1
- 수록면
- 103 - 111 (9page)
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Background: Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells. The aim of the present study was to evaluate the immunohistochemical expression of female sex hormone receptors in lung ADC and determine the expression patterns in patients with different clinicopathological characteristics. Methods: A total of 84 patients with lung ADC who underwent surgical resection and/or core biopsy were recruited for the present study. Immunohistochemical staining was performed for estrogen receptor α (ERα), estrogen receptor β (ERβ), progesterone receptor (PR), epidermal growth factor receptor (EGFR), EGFR E746-A750 del, and EGFR L858R using tissue microarray. Results: A total of 39 (46.4%) ERα-positive, 71 (84.5%) ERβ-positive, and 46 (54.8%) PR-positive lung ADCs were identified. In addition, there were 81 (96.4%) EGFR-positive, 14 (16.7%) EGFR E746-A750 del–positive, and 34 (40.5%) EGFR L858R–positive cases. The expression of female sex hormone receptors was not significantly different in clinicopathologically different subsets of lung ADC. Conclusions: Expression of female sex hormone receptors is not associated with the prognosis and clinicopathological characteristics of patients with lung ADC.
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참고문헌 (42)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Omoto Y / 2001 / Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers / Biochem Biophys Res Commun 285:340~347
Yano T / 2008 / Never-smoking nonsmall cell lung cancer as a separate entity : clinicopathologic features and survival / Cancer 113:1012~1018
Torday JS / 1981 / Sex differences in fetal lung maturation / Am Rev Respir Dis 123:205~208
Taioli E / 1994 / Re : Endocrine factors and adenocarcinoma of the lung in women / J Natl Cancer Inst 86:869~870
Omoto Y / 2001 / Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers / Biochem Biophys Res Commun 285:340~347
Yano T / 2008 / Never-smoking nonsmall cell lung cancer as a separate entity : clinicopathologic features and survival / Cancer 113:1012~1018
Torday JS / 1981 / Sex differences in fetal lung maturation / Am Rev Respir Dis 123:205~208
Taioli E / 1994 / Re : Endocrine factors and adenocarcinoma of the lung in women / J Natl Cancer Inst 86:869~870
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