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ObjectiveBRCA mutational status is important in the management of ovarian cancer, but there is a lack of evidence supportinggenetic testing in Asian populations. This study was performed to investigate the prevalence and prognostic outcomesof BRCA1/2 mutation and variant of unknown significance (VUS) in Korean patients diagnosed with epithelial ovariancancer (EOC). MethodsAmong patients newly diagnosed with EOC between January 2007 and January 2017, those tested for germlineBRCA1/2 mutation were studied, regardless of family history. Overall survival (OS) and progression-free survival (PFS)were compared between the patients with and without BRCA1/2 mutation and VUS. ResultsA total of 313 patients underwent BRCA testing: 88 patients had a BRCA1/2 mutation and 48 patients had a BRCA1/2VUS (28.1% and 15.3%, respectively). There were no significant associations between BRCA1/2 mutation, BRCA1/2wild-type, or BRCA1/2 VUS with age at diagnosis, histologic distribution, or residual disease status after primarycytoreductive surgery. BRCA1 mutation, including BRCA1 VUS, showed no difference in PFS or OS compared to BRCA1wild-type. In contrast, BRCA2 mutation showed longer PFS than that of BRCA2 wild-type (P=0.04) or BRCA2 VUS(P=0.02). BRCA2 mutation, including BRCA2 VUS, did not show any difference in OS compared to BRCA2 wild-type. ConclusionBRCA mutation and BRCA VUS had similar clinical characteristics and survival outcomes, except that BRCA2 mutationshowed better PFS. The results of this study will help to understand the prognostic significance of BRCA mutation andVUS in Korean patients.

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