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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 940 - 947 (8page)
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Objective Although the pathogenesis of depression remains unclear, C-reactive protein (CRP) levels are commonly elevated in depressed patients. Thus, CRP single-nucleotide polymorphisms (SNPs) that influence CRP levels may be associated with depression. In the present study, we explored whether CRP SNPs are related to depressive symptoms and antidepressants efficacy in Han Chinese patients. Methods We analyzed data from 440 patients with first-episode depression. We obtained genome CRP SNPs, scores of the 17-item Hamilton Rating Scale for Depression 17 (HAMD17) and its four-factor at baseline and after 6 weeks. Quantitative trait analysis was performed using UNPHASED software and curative effects were analyzed using SPSS software. Results Male patients with SNP rs1800947G exhibited lower insomnia scores and rs2794521CC exhibited lower scores of anxiety/ physical symptoms, total HAMD17 score. Female patients with rs2794521TT exhibited higher scores of insomnia and lower antidepressants efficacy. Conclusion CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sex-specific fashion. Furthermore, rs2794521 may be a predictor of the efficacy of antidepressants in female patients.
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참고문헌 (40)
참고문헌 신청
Sumiyoshi T / 2018 / Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder in Japan(PERFORM-J) : protocol for a prospective cohort study / JMIR Res Protoc 7:e161
Kohler CA / 2018 / Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder : systematic review and meta-analysis / Mol Neurobiol 55:4195~4206
Ma L / 2017 / Animal inflammation-based models of depression and their application to drug discovery / Expert Opin Drug Discov 12:995~1009
Lopresti AL / 2017 / Cognitive behaviour therapy and inflammation : a systematic review of its relationship and the potential implications for the treatment of depression / Aust N Z J Psychiatry 51:565~582
Horn SR / 2018 / Replication and reproducibility issues in the relationship between C-reactive protein and depression : a systematic review and focused metaanalysis / Brain Behav Immun 73:85~114
Kohler CA / 2018 / Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder : systematic review and meta-analysis / Mol Neurobiol 55:4195~4206
Ma L / 2017 / Animal inflammation-based models of depression and their application to drug discovery / Expert Opin Drug Discov 12:995~1009
Lopresti AL / 2017 / Cognitive behaviour therapy and inflammation : a systematic review of its relationship and the potential implications for the treatment of depression / Aust N Z J Psychiatry 51:565~582
Horn SR / 2018 / Replication and reproducibility issues in the relationship between C-reactive protein and depression : a systematic review and focused metaanalysis / Brain Behav Immun 73:85~114
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