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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 579 - 586 (8page)
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초록· 키워드
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Objective Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.Methods 953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.Results There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.Conclusion Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.
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참고문헌 (52)
참고문헌 신청
Galvez-Contreras AY / 2016 / Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders / Cytokine Growth Factor Rev 32:85~96
Gururajan A / 2016 / Molecular biomarkers of depression / Neurosci Biobehav Rev 64:101~133
Lai CY / 2016 / Biomarkers in schizophrenia : a focus on blood based diagnostics and theranostics / World J Psychiatry 6:102~117
Okazaki S / 2016 / The cell cycle-related genes as biomarkers for schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 70:85~91
Karlović D / 2012 / Serum concentrations of CRP, Il-6, TNF-α, and cortisol in major depressive disorder with melancholic or atypical features / Psychiatry Res 198:74~80
Gururajan A / 2016 / Molecular biomarkers of depression / Neurosci Biobehav Rev 64:101~133
Lai CY / 2016 / Biomarkers in schizophrenia : a focus on blood based diagnostics and theranostics / World J Psychiatry 6:102~117
Okazaki S / 2016 / The cell cycle-related genes as biomarkers for schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 70:85~91
Karlović D / 2012 / Serum concentrations of CRP, Il-6, TNF-α, and cortisol in major depressive disorder with melancholic or atypical features / Psychiatry Res 198:74~80
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