Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

Joon Sul Choi; Ji Hyun Lee; Suk Ki Park; Beom Jin Shim; Won Kyu Choi; Sang Hyun Kim; Seon Chool Hwang

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자료유형: 학술저널

저자정보: Joon Sul Choi (Maryknoll Medical Center) Ji Hyun Lee (Maryknoll Medical Center) Suk Ki Park (Maryknoll Medical Center) Beom Jin Shim (Maryknoll Medical Center) Won Kyu Choi (Maryknoll Medical Center) Sang Hyun Kim (Maryknoll Medical Center) Seon Chool Hwang (Maryknoll Medical Center)

저널정보: 대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제23권 제5호

발행연도: 2016.1

수록면: 332 - 335 (4page)

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Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system receptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers of drugs and drug combinations, and serotonin-norepinephrine reuptake inhibitor-induced serotonin syndrome is rare. It is often described as a sign of excess serotonin ranging from tremor in mild cases to delirium, neuromuscular rigidity, and hyperthermia in life-threatening cases. Diagnosis is based on the symptoms and patient’s history, and several diagnostic criteria have been developed. We experienced a rare case of fibromyalgia accompanied by tremor, hyperreflexia, spontaneous clonus, muscle rigidity, and diaphoresis after 10 days of single use of duloxetine 30 mg. Only one case of serotonin syndrome resulting from administration of duloxetine has been reported in Korea, however that case resulted from co-administration of fluoxetine. We report here on this case along with a review of the relevant literature. (J Rheum Dis 2016;23:332-335)

참고문헌 (10)

참고문헌 신청

Boyer EW / 2005 / The serotonin syndrome / N Engl J Med 352:1112~1120

Gaffney RR / 2015 / Serotonin syndrome in a patient on trazodone and duloxetine who received fentanyl following a percutaneous liver biopsy / Case Rep Gastroenterol 9:132~136

Gollapudy S / 2012 / A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion / J Clin Anesth 24:251~252

Gelener P / 2011 / Serotonin syndrome due to duloxetine / Clin Neuropharmacol 34:127~128

유승민 / 2012 / 치료용량의 Fluoxetine과 Duloxetine을 사용한 뒤 각 약물에 의해 독립적으로 동일 환자에서 발생한 세로토닌 증후군 1예 / 대한정신약물학회지 23(2):74~77

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