지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 58 - 65 (8page)
이용수
초록· 키워드
오류제보하기
Background: The quantitative interferon (IFN)-γ response in the IFN-γ release assay (IGRA) has been investigated to predict progression from Mycobacterium tuberculosis infection to active tuberculosis (TB). However, the significance of the quantitative IFN-γ response in active TB is rarely known. We assessed the association between IFN-γ response to nil, mitogen, and TB mycobacterial antigens, and the variations from serial IGRA testing in active TB of various primary infection sites. Methods: In total, 102 active TB patients with serial QuantiFERON-TB Gold In-Tube (QFT-GIT) (Qiagen, Germany) were enrolled. The medical records of patients were reviewed for demographic information, infection sites, tuberculosis treatment, and the quantitative IFN-γ response to nil, mitogen, and TB antigen. Results: Patients included 20, 68, and 14 cases of pulmonary TB, extrapulmonary TB, and multiple TB infection, respectively. The quantitative IFN-γ responses to TB antigens differed significantly according to the infection sites ( P =0.0001). The median IFN-γ response was the highest in lymph node infection (10.0 IU/mL) and the lowest in central nervous system (CNS) infection (0.02 IU/mL). Of the total, 86.3% showed concordant results in serial testing. Both 50% of the patients with persistent negative results and 62.5% of patients with CNS TB had an insufficient IFN-γ response to mitogen. Conclusions: Different IFN-γ responses to TB antigens may indicate variable host immune responses among infection sites in active TB disease. Because a few active TB patients fail to produce an adequate IFN-γ response, a study of cellular mechanisms is needed in such unresponsive patients.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea
Yonsei Medical Journal
2019 .01
-
의료기관에서의 결핵예방과 결핵환자 격리
대한의사협회지
2019 .01
-
Species Specific Antiviral Activity of Porcine Interferon-α8 (IFNα8)
Immune Network
2017 .12
-
간호대학생의 결핵에 대한 지식 및 태도가 결핵감염 예방행위에 미치는 영향
기초간호자연과학회지
2016 .01
-
환자와 의료기관 종사자에서 QuantiFERON-TB Gold-Plus 양성 패턴과 추적 결과 분석
Laboratory Medicine Online
2023 .04
-
국내 소아 결핵감염 진단에서의 결핵피부반응 검사와 Interferon-gamma Release Assay (IGRA)의 비교 연구
Pediatric Infection and Vaccine
2016 .01
-
한국 대학생의 결핵 예방행위에 대한 영향요인: 결핵 관련 지식, 태도 및 낙관적 편견을 중심으로
기본간호학회지
2020 .08
-
Effects of Interferon Beta in COVID-19 adult patients: Systematic Review
Infection and Chemotherapy
2021 .01
-
Comparative evaluation of QuantiFERON-TB Gold Plus for diagnosis of latent tuberculosis infection during solid organ transplantation
Clinical Transplantation and Research
2020 .01
-
Repeatability of QuantiFERON-TB Gold In-Tube Assay Results Near Cut-Off Points
Annals of Laboratory Medicine
2016 .01
-
다제내성결핵의 진단과 치료
대한내과학회지
2015 .01
-
림프절 결핵
대한내과학회지
2015 .01
-
결핵전문병원에 입원한 결핵환자의 우울증위험인자
정신신체의학
2015 .01
-
A Pilot Project of Systematic Tuberculosis Screening in the Elderly in a South Korean Province
Tuberculosis and Respiratory Diseases
2019 .01
-
Tuberculosis Infection and Latent Tuberculosis
Tuberculosis and Respiratory Diseases
2016 .01
-
폐결핵 치료의 최신지견
대한의사협회지
2019 .01
-
The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
Blood Research
2021 .04
-
The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
Blood Research
2021 .01
-
Knowledge, Attitudes, and Practices Regarding Tuberculosis in Timor-Leste: Results From the Demographic and Health Survey 2016
예방의학회지
2019 .01
-
Interferon-gamma Release Assay의 임상적 이용
Laboratory Medicine Online
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0