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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제1호
- 발행연도
- 2020.1
- 수록면
- 58 - 66 (9page)
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초록· 키워드
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Objective: Frontal alpha asymmetry (FAA) of electroencephalography (EEG) has been studied to differentiate patients with major depressive disorder (MDD) from healthy controls (HC). However, inconsistent results have been obtained thus far. Suicidal ideation (SI) has been known to alter frontal lobe activity, and could be an important covariate in FAA studies. This study aimed to explore the influence of FAA on the relationship among MDD patients with SI and without SI, and HC. Methods: Sixty-seven patients with MDD (44 without and 23 with SI) and 60 HCs were recruited. Resting state EEG was recorded with their eyes open, and FAA as a lateralized index of alpha power was calculated in the frontal brain region. Hamilton Rating Scale for Anxiety and Depression scores were estimated. Results: FAA was higher (increased alpha power in the left frontal region) in the MDD group than in the HC group. The FAA was lower (reduced alpha power in the left frontal region) in MDD patients with SI than in MDD patients without SI. The severity of depression and anxiety symptoms were significantly correlated with FAA only in MDD patients with SI. SI moderated the effects of depressive symptom on FAA in the MDD group. Conclusion: Our results suggest that SI is a clinically important moderator of frontal alpha asymmetry in patients with MDD.
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등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Alonso J / 2004 / Prevalence of mental disorders in Europe : results from the European Study of the Epidemiology of Mental Disorders(ESEMeD)project / Acta Psychiatr Scand Suppl (420):21~27
Kessler RC / 2005 / Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:593~602
Murray CJ / 1997 / Alternative projections of mortality and disability by cause 1990-2020 : Global Burden of Disease Study / Lancet 349:1498~1504
American Psychiatric Association / 2000 / Diagnostic and statistical manual of mental disorders: DSM-IV-TR / American Psychiatric Association
Iosifescu DV / 2008 / Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder / Acta Psychiatr Scand 117:271~276
Kessler RC / 2005 / Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:593~602
Murray CJ / 1997 / Alternative projections of mortality and disability by cause 1990-2020 : Global Burden of Disease Study / Lancet 349:1498~1504
American Psychiatric Association / 2000 / Diagnostic and statistical manual of mental disorders: DSM-IV-TR / American Psychiatric Association
Iosifescu DV / 2008 / Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder / Acta Psychiatr Scand 117:271~276
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