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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 10 (10page)
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Background: Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval. Methods: Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates. Results: PD elevated the risk of subsequent MDD by 1.5-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years. Conclusion: The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.
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참고문헌 (39)
참고문헌 신청
Clayton PJ / 1990 / The comorbidity factor: establishing the primary diagnosis in patients with mixed symptoms of anxiety and depression / J Clin Psychiatry 51(Suppl):35~39
Roy-Byrne PP / 2000 / Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairment, course and help-seeking / Br J Psychiatry 176(3):229~235
Dolan RJ / 1994 / Neuropsychological dysfunction in depression : the relationship to regional cerebral blood flow / Psychol Med 24(4):849~857
Nordahl TE / 1990 / Cerebral glucose metabolic differences in patients with panic disorder / Neuropsychopharmacology 3(4):261~272
Merikangas KR / 1996 / Comorbidity and boundaries of affective disorders with anxiety disorders and substance misuse : results of an international task force / Br J Psychiatry Suppl 168(30):58~67
Roy-Byrne PP / 2000 / Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairment, course and help-seeking / Br J Psychiatry 176(3):229~235
Dolan RJ / 1994 / Neuropsychological dysfunction in depression : the relationship to regional cerebral blood flow / Psychol Med 24(4):849~857
Nordahl TE / 1990 / Cerebral glucose metabolic differences in patients with panic disorder / Neuropsychopharmacology 3(4):261~272
Merikangas KR / 1996 / Comorbidity and boundaries of affective disorders with anxiety disorders and substance misuse : results of an international task force / Br J Psychiatry Suppl 168(30):58~67
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