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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제1호
- 발행연도
- 2020.1
- 수록면
- 93 - 108 (16page)
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Objective: The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages. Methods: Cynomolgus monkeys were divided by age as follows: 1 year (A1, n = 2); 3 to 4 years (A2, n = 2); 6 to 8 years (A3, n = 2); and older than 11 years (A4, n = 2). After heroin was injected intramuscularly into the monkeys (0.6 mg/kg), we performed large-scale transcriptome profiling in the hippocampus (H) and striatum (S) using RNA sequencing technology. Some genes were validated with real-time quantitative PCR. Results: In the hippocampus, the gene expression of A1H was similar to that of A4H, while the gene expression of A2H was similar to that of A3H. Genes associated with the mitogen-activated protein kinase signaling pathway (STMN1, FGF14, and MAPT) and -aminobutyric acid-ergic synapses (GABBR2 and GAD1) were differentially expressed among control and heroin-treated animals. Differential gene expression between A1S and A4S was the least significant, while differential gene expression between A3S and A2S was the most significant. Genes associated with the neurotrophin signaling pathway (NTRK1 and NGFR), autophagy (ATG5), and dopaminergic synapses (AKT1) in the striatum were differentially expressed among control and heroin-treated animals. Conclusion: These results suggest that even a single heroin exposure can cause differential gene expression in the hippocampus and striatum of nonhuman primates at different ages.
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참고문헌 (65)
참고문헌 신청
Alcohol and Drug Abuse Statistics
United Nations Office on Drugs and Crime / World Drug Report 2015
Pattij T / 2008 / The neuropharmacology of impulsive behaviour / Trends Pharmacol Sci 29:192~199
Lazarov O / 2016 / Hippocampal neurogenesis: learning to remember / Prog Neurobiol 138-140:1~18
Tramullas M / 2008 / Chronic administration of heroin to mice produces up-regulation of brain apoptosis-related proteins and impairs spatial learning and memory / Neuropharmacology 54:640~652
United Nations Office on Drugs and Crime / World Drug Report 2015
Pattij T / 2008 / The neuropharmacology of impulsive behaviour / Trends Pharmacol Sci 29:192~199
Lazarov O / 2016 / Hippocampal neurogenesis: learning to remember / Prog Neurobiol 138-140:1~18
Tramullas M / 2008 / Chronic administration of heroin to mice produces up-regulation of brain apoptosis-related proteins and impairs spatial learning and memory / Neuropharmacology 54:640~652
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