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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
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Background: The present study investigates the potent skin whitening ability of ethanol extract from the brown alga, Padina boryana (PBE) which was collected in the shores of Fulhadhoo Island, the Maldives, and its specific pathways of action. The effect of PBE which contains a rich amount of polyphenols was evaluated using B16F10 murine melanoma cells and provides insight to the underlying mechanisms with reference to the inhibition of melanin formation. Methods: Melanin synthesis and cellular tyrosinase inhibition were assessed in the α-MSH-stimulated melanocytes. Melanogenic pathway-related protein expressions were investigated via Western blotting. ERK 42/44 was particularly examined considering its involvement in the melanogenic pathway. Further, RT-qPCR techniques were involved in gene expression analysis. Results: PBE dose-dependently inhibited the cellular melanin synthesis and tyrosinase levels. Western blotting revealed the potential of PBE to downregulate microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinaserelated protein-1 and protein-2 (TRP-1 and TRP-2). Moreover, results explained the phosphorylation of ERK was sustained via PBE and hence declined the ultimate melanin synthesis. Gene expression analysis reinforced the results obtained. Conclusions: The study provides substantial evidence to express the potential of PBE to inhibit B16F10 melanoma cell melanin synthesis. Concisely, results suggest the ability of PBE to be involved in medicinal and cosmeceutical applications.
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참고문헌 (38)
참고문헌 신청
Agar N / 2005 / Melanogenesis: a photoprotective response to DNA damage? / Mutat Res 571:121~132
Arung ET / 2011 / Antimelanogenesis properties of quercetin-and its derivative-rich extract from Allium cepa / Food chemistry 124:1024~1028
Bae J-S / 2016 / Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK / Chemico-biological interactions 245:66~71
Boonme P / 2009 / Microemulsions and nanoemulsions : novel vehicles for whitening cosmeceuticals / J Biomed Nanotechnol 5:373~383
Chan YY / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells / J Ethnopharmacol 137:1183~1188
Arung ET / 2011 / Antimelanogenesis properties of quercetin-and its derivative-rich extract from Allium cepa / Food chemistry 124:1024~1028
Bae J-S / 2016 / Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK / Chemico-biological interactions 245:66~71
Boonme P / 2009 / Microemulsions and nanoemulsions : novel vehicles for whitening cosmeceuticals / J Biomed Nanotechnol 5:373~383
Chan YY / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells / J Ethnopharmacol 137:1183~1188
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Exploring the potent use of the Padina boryana extracts as a sources of cosmeceutical materials for it’s anti-UV and anti-wrinkle activities
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