Whitening Effect of Watersoluble Royal Jelly from South Korea

Han, Sang Mi; Kim, Jung Min; Hong, In Phyo; Woo, Soon Ok; Kim, Se Gun; Jang, Hye Ri; Park, Kwan Kyu; Pak, Sok Cheon

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자료유형: 학술저널

저자정보: Han, Sang Mi (Department of Agricultural Biology, National Academy of Agricultural Science) Kim, Jung Min (Department of Agricultural Biology, National Academy of Agricultural Science) Hong, In Phyo (Department of Agricultural Biology, National Academy of Agricultural Science) Woo, Soon Ok (Department of Agricultural Biology, National Academy of Agricultural Science) Kim, Se Gun (Department of Agricultural Biology, National Academy of Agricultural Science) Jang, Hye Ri (Department of Agricultural Biology, National Academy of Agricultural Science) Park, Kwan Kyu (Catholic University of Daegu School of Medicine) Pak, Sok Cheon (School of Biomedical Sciences, Charles Sturt University)

저널정보: 한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제35권 제5호

발행연도: 2015.1

수록면: 707 - 713 (7page)

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Royal jelly has been widely used as a health supplement worldwide. However, royal jelly has been implicated in allergic reactions, and we developed a water-soluble royal jelly (WSRJ) without the allergy inducing protein. In this study, we aimed to identify the anti-melanogenic efficacy of WSRJ. B16F1 melanoma cells were first treated with 10 nM α-melanocyte stimulating hormone (α-MSH) and then with various doses of WSRJ. In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting. WSRJ directly inhibited tyrosinase and cellular tyrosinase activity, which decreased melanin synthesis in α-MSH stimulated B16F1 melanoma cells a level comparable to that observed with arbutin. WSRJ decreased the mRNA and protein expressions of tyrosinase, TRP-1, and TRP-2, which was comparable to that observed with arbutin. WSRJ has strong anti-melanogenic activity, which invoice direct inhibition of tyrosinase enzyme activity and suppression of expression of melanogenesis related genes. Results from this study suggests that WSRJ is a potential candidate for the treatment of skin pigmentation.

#α-MSH #royal jelly #water-soluble royal jelly #tyrosinase #TRP-1 #TRP-2

참고문헌 (23)

참고문헌 신청

Ando, H. / 1999 / Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis / J. Lipid Res 40:1312~1316

Barsh, G. S. / 1996 / The genetics of pigmentation: From fancy genes to complex traits / Trends Genet 12:299~305

Buscà, R. / 2000 / Cyclic AMP a key messenger in the regulation of skin pigmentation / Pigment Cell Res 13:60~69

Te-Sheng Chang / 2012 / Inhibitory Effect of Homochlorcyclizine on Melanogenesis in α-Melanocyte Stimulating Hormone-stimulated Mouse B16 Melanoma Cells / Archives of Pharmacal Research 35(1):119~127

Food and Agriculture Organization of the United Nations / Value-added products from beekeeping

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