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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Interleukin-17 (IL-17) is secreted by a class of helper T cells called Th17 cells, which stimulates keratinocytes to secrete proinflammatory mediator and to recruit other inflammatory cells in psoriatic skins. IL-17A inhibitor was approved for the management of psoriatic arthritis by FDA. It is the one of the biologics approved as first-line therapy for the management of psoriasis. But several studies show some side effects of IL-17A inhibitor such as upper respiratory infection and fungal infection like Candida albicans. Herein we report a widespread dermatophytosis during IL-17A inhibitor treatment. A 66-year-old male patient, with tinea unguium and chronic plaque psoriasis for several decades, presented with multiple erythematous scaly macules and patches for 2 weeks. He medicated IL-17A inhibitor for treating psoriasis total 3 times and last injection was 1 week ago. Dermatological examination revealed the involvement of 20% body surface area in the form of erythematous scaly macules and patches. KOH mount revealed the presence of numerous hyphae. The patient was started on oral terbinafine, topical isoconazole and efinaconazole. His skin lesions were improved after 1 month of anti-fungal therapy. IL-17 plays an important role in mucocutaneous microbial defense. So, fungal infection should be checked in using IL-17A inhibitor patients periodically.
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등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
Sparber F / 2019 / Interleukin-17 in antifungal immunity / Pathogens 8:E54
Neema S / 2019 / Widespread superficial dermatophytosis in patient on secukinumab for treatment of chronic plaque psoriasis / Indian Dermatol Online J 10:76~78
Ohtsuki M / 2014 / Secukinumab efficacy and safety in Japanese patients with moderate‐to‐severe plaque psoriasis: Subanalysis from ERASURE, a randomized, placebo-controlled, phase 3 study / J Dermatol 41:1039~1046
Quach OL / 2016 / Perianal dermatophytosis during secukinumab therapy for plaque psoriasis / JAMA Dermatol 152:486~487
Marinoni B / 2014 / The Th17axis in psoriatic disease: Pathogenetic and therapeutic implications / Auto Immun Highlights 5:9~19
Neema S / 2019 / Widespread superficial dermatophytosis in patient on secukinumab for treatment of chronic plaque psoriasis / Indian Dermatol Online J 10:76~78
Ohtsuki M / 2014 / Secukinumab efficacy and safety in Japanese patients with moderate‐to‐severe plaque psoriasis: Subanalysis from ERASURE, a randomized, placebo-controlled, phase 3 study / J Dermatol 41:1039~1046
Quach OL / 2016 / Perianal dermatophytosis during secukinumab therapy for plaque psoriasis / JAMA Dermatol 152:486~487
Marinoni B / 2014 / The Th17axis in psoriatic disease: Pathogenetic and therapeutic implications / Auto Immun Highlights 5:9~19
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