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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 280 - 293 (14page)
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Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish stellate cells from hepatic fibroblast-derived myofibroblasts. Loss of Cygb accelerates liver fibrosis and cancer development in mouse models of chronic liver injury including diethylnitrosamine-induced hepatocellular carcinoma, bile duct ligation-induced cholestasis, thioacetamide-induced hepatic fibrosis, and choline-deficient L-amino aciddefined diet-induced non-alcoholic steatohepatitis. This review focuses on the history of research into the role of reactive oxygen species and nitrogen species in liver fibrosis and discusses the current perception of Cygb as a novel radical scavenger with an emphasis on its role in hepatic stellate cell activation and fibrosis.
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참고문헌 (159)
참고문헌 신청
Friedman SL / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134:1655~1669
Pinzani M / 2004 / Liver fibrosis : from the bench to clinical targets / Dig Liver Dis 36:231~242
Comporti M / 1965 / Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions / Enzymologia 29:185~204
Ghoshal AK / 1965 / Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: in vitro experiments / Life Sci 4:1521~1530
Di Luzio NR / 1967 / Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver / Fed Proc 26:1436~1442
Pinzani M / 2004 / Liver fibrosis : from the bench to clinical targets / Dig Liver Dis 36:231~242
Comporti M / 1965 / Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions / Enzymologia 29:185~204
Ghoshal AK / 1965 / Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: in vitro experiments / Life Sci 4:1521~1530
Di Luzio NR / 1967 / Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver / Fed Proc 26:1436~1442
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