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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe3O4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe3O4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate and MTT assays as well as flow cytometer on ALL cancer cell lines. Results: Different evaluations indicated that the drug delivery vehicle had a mean diameter size around 12ƞm with well bounded components. This system presented high degree of magnetization and superparamagnetic properties as well as good water solubility. In comparison with pure genistein, significant growth inhibition on hematopoietic cancer cells in lower dose of genistein nano-conjugated onto Fe3O4-CMC. It increased long lasting effect of genistein in cancer cells also. Conclusion: This delivery system for genistein could be remarkably promised and futuristic as biocompatible chemotherapeutic agent against hematopoietic malignant cells.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Yezhelyev MV / 2006 / Emerging use of nanoparticles in diagnosis and treatment of breast cancer / Lancet Oncol 7(8):657~667
Dorniani D / 2013 / Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system / Drug Des Devel Ther 7:1015~1026
Hou CH / 2009 / The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy / Biomaterials 30(23?24):3956~3960
Lin JJ / 2009 / Folic acid-Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications / Biomaterials 30(28):5114~5124
Sun C / 2008 / Magnetic nanoparticles in MR imaging and drug delivery / Adv Drug Deliv Rev 60(11):1252~1265
Dorniani D / 2013 / Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system / Drug Des Devel Ther 7:1015~1026
Hou CH / 2009 / The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy / Biomaterials 30(23?24):3956~3960
Lin JJ / 2009 / Folic acid-Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications / Biomaterials 30(28):5114~5124
Sun C / 2008 / Magnetic nanoparticles in MR imaging and drug delivery / Adv Drug Deliv Rev 60(11):1252~1265
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Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans
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