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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 79 - 87 (9page)
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Purpose: This study aimed to elucidate the molecular mechanisms of the anti-pancreatic fibrosis effects of matrine in rats. Materials and Methods: Trinitrobenzene sulfonic acid was administrated to rats to establish a pancreatic fibrosis model. Rats weredivided into four groups: Control, Sham, Model, and Matrine (n=8). Hematoxylin-eosin staining, Masson staining, and Azan stainingwere performed to evaluate pancreatic fibrosis. Expression of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin(α-SMA), and collagen I in pancreatic tissues was evaluated by immunohistochemical staining. mRNA and protein levels of TGF-βreceptor 1 (TβR1), TβR2, and Smad2 in pancreatic tissues were determined by RT-PCR and Western blot, respectively. Results: In the model group, hyperplasia of glandules around the glandular ducts, mitochondrial swelling of acinous cells, andsevere fibrosis were found. Interestingly, in the Matrine group, mitochondrial swelling was only found in a small number of acinouscells, and the fundamental structures of pancreatic tissues were intact. Moreover, pancreatic fibrosis was markedly alleviated. Comparing to the Sham group, expression of α-SMA, TGF-β1, and collagen I was sharply elevated in the Model group (p<0.05);however, their expressions were much lower in the Matrine group, compared to the Model group (p<0.05). Compared with theSham group, mRNA and protein levels of Smad2, TβR1, and TβR2 in the Model group were notably raised (p<0.05). However,their high expression was significantly downregulated in the Matrine group (p<0.05). Conclusion: Matrine suppressed pancreatic fibrosis by regulating TGF-β/Smad signaling in rats.
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참고문헌 (29)
참고문헌 신청
Xue J / 2015 / Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis / Nat Commun 6:7158
Tanaka K / 2015 / Significance of histopathological evaluation of pancreatic fibrosis to predict postoperative course after pancreatic surgery / Anticancer Res 35:1749~1756
Lu X / 2016 / Pathologic assessment of pancreatic fibrosis in predicting pancreatic fistula and management of prophylactic drain removal after pancreaticoduodenectomy / World J Surg 40:1520~1521
Nagathihalli NS / 2016 / Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells / Oncotarget 7:65982~65992
Tjomsland V / 2016 / The TGFβ-SMAD3 pathway inhibits IL-1αinduced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration / J Exp Clin Cancer Res 35:122
Tanaka K / 2015 / Significance of histopathological evaluation of pancreatic fibrosis to predict postoperative course after pancreatic surgery / Anticancer Res 35:1749~1756
Lu X / 2016 / Pathologic assessment of pancreatic fibrosis in predicting pancreatic fistula and management of prophylactic drain removal after pancreaticoduodenectomy / World J Surg 40:1520~1521
Nagathihalli NS / 2016 / Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells / Oncotarget 7:65982~65992
Tjomsland V / 2016 / The TGFβ-SMAD3 pathway inhibits IL-1αinduced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration / J Exp Clin Cancer Res 35:122
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