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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 148 - 157 (10page)
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Purpose: Breast cancer (BC) is one of the most common malignant tumors, affecting a significant number of women worldwide. MicroRNAs (miRNAs) have been reported to play important roles in tumorigenesis. The aim of this study was to determine theroles of miR-182-5p in BC progression. Materials and Methods: The expressions of miR-182-5p and phosphatase and tensin homolog deleted on chromosome 10(PTEN) were measured in BC tissues and cells by quantitative real-time polymerase chain reaction or Western blot. Cell proliferationand invasion were detected by cell counting kit-8 assay and trans-well assay, respectively. The interaction between miR-182-5p and PTEN was probed by bioinformatics analysis, luciferase activity, and RNA immunoprecipitation. A murine xenograftmodel was established to investigate the role of miR-182-5p in BC progression in vivo. Results: An abundance of miR-182-5p was noted in BC tissues and cells. High expression of miR-182-5p was associated with poorsurvival. Abrogation of miR-182-5p inhibited cell proliferation and invasion in BC cells. Interestingly, PTEN was indicated as atarget of miR-182-5p, and its restoration reversed miR-182-5p-mediated promotion of proliferation and invasion of BC cells. Moreover, depletion of miR-182-5p suppressed tumor growth via up-regulating PTEN expression in the murine xenograft model. Conclusion: MiR-182-5p exhaustion blocked cell proliferation and invasion by regulating PTEN expression, providing a noveltherapeutic avenue for treatment of BC.
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참고문헌 (30)
참고문헌 신청
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Varghese F / 2018 / Breast cancer in the elderly / Surg Clin North Am 98:819~833
Greenwood HI / 2018 / Impact of advancing technology on diagnosis and treatment of breast cancer / Surg Clin North Am 98:703~724
Mandujano-Tinoco EA / 2018 / New emerging roles of microRNAs in breast cancer / Breast Cancer Res Treat 171:247~259
O’Bryan S / 2017 / The roles of oncogenic miRNAs and their therapeutic importance in breast cancer / Eur J Cancer 72:1~11
Varghese F / 2018 / Breast cancer in the elderly / Surg Clin North Am 98:819~833
Greenwood HI / 2018 / Impact of advancing technology on diagnosis and treatment of breast cancer / Surg Clin North Am 98:703~724
Mandujano-Tinoco EA / 2018 / New emerging roles of microRNAs in breast cancer / Breast Cancer Res Treat 171:247~259
O’Bryan S / 2017 / The roles of oncogenic miRNAs and their therapeutic importance in breast cancer / Eur J Cancer 72:1~11
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