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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제8호
발행연도
2019.1
수록면
768 - 773 (6page)

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Purpose: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has become a standard treatment for medicallyintractable essential tremor (ET). Skull density ratio (SDR) and skull volume in patients with ET are currently considereduseful indicators of the successful application of MRgFUS. We compared the clinical outcomes of MRgFUS thalamotomy withSDR above 0.4 and 0.45. We also described patterns of SDR and skull volume in Korean patients with ET who were eligible to bescreened for MRgFUS. Materials and Methods: In screening 318 ET patients, we evaluated patterns of skull density and skull volume according to ageand sex. Fifty patients with ET were treated with MRgFUS. We investigated the effects of SDR and skull volume on treatment parametersand the outcomes of ET. Results: The mean SDR of the 318 ET patients was 0.45±0.11, and that for skull volume was 315.74±40.95 cm3. The male patientshad a higher SDR than female patients (p=0.047). Skull volume significantly decreased with aging. SDR and skull volume exhibiteda linear negative relationship. Among therapeutic parameters, maximal temperature was positively related to SDR, while sonicationnumber was not related to either SDR or skull volume. Tremor outcome was also not related to SDR or skull volume. Conclusion: SDR varied widely from 0.11 to 0.73, and men had a higher SDR. Therapeutic parameters and clinical outcomeswere not affected by SDR or skull volume.

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