지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,021 - 1,027 (7page)
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초록· 키워드
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Purpose: Computed tomography (CT) is the most useful diagnostic modality for staging renal cell carcinoma (RCC). However,CT is limited in its ability to predict renal sinus fat invasion (SFI). Here, we aimed to evaluate whether preoperative neutrophil-tolymphocyteratio (NLR) could predict pathological SFI in patients with RCC of ≤7 cm for whom preoperative imaging reveals potentialrenal SFI. Materials and Methods: We reviewed the medical records of 1311 patients who underwent extirpative renal surgery for non-metastaticRCC of ≤7 cm between November 2005 and December 2014. After excluding patients with no SFI in preoperative imaging, unavailablepreoperative data, and morbidity affecting inflammatory markers, a total of 476 patients were included in this study. Multivariatelogistic regression analysis was used to evaluate predictors of pathological SFI. Results: We implemented a cut-off value of 1.98, which was calculated by ROC analysis to obtain high (≥1.98) and low (<1.98) NLRgroups. A total of 93 patients with pathological SFI had larger clinical tumor size, higher preoperative NLR, larger pathological tumorsize, more frequent renal vein involvement, and higher Fuhrman nuclear grade. Multivariate analysis indicated that high NLR[odds ratio (OR) 2.032, p=0.004], clinical tumor size (OR 1.586, p<0.001), and collecting system involvement on preoperative imaging(OR 3.957, p=0.011) were significantly associated with pathological SFI in these tumors. Conclusion: Preoperative high NLR was associated with pathological SFI in patients with RCC of ≤7 cm and presumed SFI on preoperativeimaging. Greater surgical attention is needed to obtain negative margins during partial nephrectomy in these patients.
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참고문헌 (27)
참고문헌 신청
Hollingsworth JM / 2006 / Rising incidence of small renal masses : a need to reassess treatment effect / J Natl Cancer Inst 98:1331~1334
Capitanio U / 2016 / Renal cancer / Lancet 387:894~906
Edge BE / 2011 / AJCC cancer staging handbook: from the AJCC cancer staging mannual / Springer
Ramaswamy K / 2015 / Significance of pathologic T3a upstaging in clinical T1 renal masses undergoing nephrectomy / Clin Genitourin Cancer 13:344~349
Nayak JG / 2016 / Pathological upstaging of clinical T1 to pathological T3a renal cell carcinoma : a multi-institutional analysis of short-term outcomes / Urology 94:154~160
Capitanio U / 2016 / Renal cancer / Lancet 387:894~906
Edge BE / 2011 / AJCC cancer staging handbook: from the AJCC cancer staging mannual / Springer
Ramaswamy K / 2015 / Significance of pathologic T3a upstaging in clinical T1 renal masses undergoing nephrectomy / Clin Genitourin Cancer 13:344~349
Nayak JG / 2016 / Pathological upstaging of clinical T1 to pathological T3a renal cell carcinoma : a multi-institutional analysis of short-term outcomes / Urology 94:154~160
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