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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제11호
발행연도
2019.1
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1,021 - 1,027 (7page)

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Purpose: Computed tomography (CT) is the most useful diagnostic modality for staging renal cell carcinoma (RCC). However,CT is limited in its ability to predict renal sinus fat invasion (SFI). Here, we aimed to evaluate whether preoperative neutrophil-tolymphocyteratio (NLR) could predict pathological SFI in patients with RCC of ≤7 cm for whom preoperative imaging reveals potentialrenal SFI. Materials and Methods: We reviewed the medical records of 1311 patients who underwent extirpative renal surgery for non-metastaticRCC of ≤7 cm between November 2005 and December 2014. After excluding patients with no SFI in preoperative imaging, unavailablepreoperative data, and morbidity affecting inflammatory markers, a total of 476 patients were included in this study. Multivariatelogistic regression analysis was used to evaluate predictors of pathological SFI. Results: We implemented a cut-off value of 1.98, which was calculated by ROC analysis to obtain high (≥1.98) and low (<1.98) NLRgroups. A total of 93 patients with pathological SFI had larger clinical tumor size, higher preoperative NLR, larger pathological tumorsize, more frequent renal vein involvement, and higher Fuhrman nuclear grade. Multivariate analysis indicated that high NLR[odds ratio (OR) 2.032, p=0.004], clinical tumor size (OR 1.586, p<0.001), and collecting system involvement on preoperative imaging(OR 3.957, p=0.011) were significantly associated with pathological SFI in these tumors. Conclusion: Preoperative high NLR was associated with pathological SFI in patients with RCC of ≤7 cm and presumed SFI on preoperativeimaging. Greater surgical attention is needed to obtain negative margins during partial nephrectomy in these patients.

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