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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,005 - 1,012 (8page)
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초록· 키워드
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Purpose: Identification of lymph node (LN) metastasis in non-small cell lung cancer (NSCLC) is critical for disease staging and selectionof therapeutic modalities. Sometimes it is not possible to obtain LN core tissue by endobronchial ultrasound-guided transbronchialneedle aspirate (EBUS-TBNA), resulting in low diagnostic yield. Materials and Methods: In this study, 138 specimens were collected from 108 patients who underwent EBUS-TBNA under thesuspicion of LN metastasis of NSCLC. Diagnostic yields of anti-CD45 and anti-methionyl-tRNA synthetase (MRS), immunofluorescent(IF) staining on cytology specimens were compared with those of conventional cytology and positron emission tomography-computed tomography (PET-CT). Results: MRS was strongly expressed in NSCLC cells metastasized to LNs, but weakly expressed in cells at the periphery of the LNgerminal center. The majority of cells were CD20 positive, although a few cells were either CD3 or CD14 positive, indicating thatCD45 staining is required for discrimination of non-malignant LN constituent cells from NSCLC cells. When the diagnostic efficacyof MRS/CD45 IF staining was evaluated using 138 LN cellular aspirates from 108 patients through EBUS-TBNA, the sensitivity was76.7% and specificity was 90.8%, whereas those of conventional cytology test were 71.8% and 100.0%, respectively. Combining theresults of conventional cytology testing and those of PET-CT showed a sensitivity and specificity of 71.6% and 100%, and the additionof MRS/CD45 dual IF data to this combination increased sensitivity and specificity to 85.1% and 97.8%, respectively. Conclusion: MRS/CD45 dual IF staining showed good diagnostic performance and may be a good tool complementing conventionalcytology test for determining LN metastasis of NSCLC.
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참고문헌 (25)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
National Lung Screening Trial Research Team / 2011 / Reduced lung-cancer mortality with low-dose computed tomographic screening / N Engl J Med 365:395~409
Horeweg N / 2014 / Lung cancer probability in patients with CT-detected pulmonary nodules : a prespecified analysis of data from the NELSON trial of low-dose CT screening / Lancet Oncol 15:1332~1341
Infante M / 2015 / Long-term follow-up results of the DANTE trial, a randomized study of lung cancer screening with spiral computed tomography / Am J Respir Crit Care Med 191:1166~1175
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
National Lung Screening Trial Research Team / 2011 / Reduced lung-cancer mortality with low-dose computed tomographic screening / N Engl J Med 365:395~409
Horeweg N / 2014 / Lung cancer probability in patients with CT-detected pulmonary nodules : a prespecified analysis of data from the NELSON trial of low-dose CT screening / Lancet Oncol 15:1332~1341
Infante M / 2015 / Long-term follow-up results of the DANTE trial, a randomized study of lung cancer screening with spiral computed tomography / Am J Respir Crit Care Med 191:1166~1175
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