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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 186 - 191 (6page)
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초록· 키워드
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An outbreak of fatal humidifier disinfectant lung injuries (HDLI) occurred in Korea. Human studies on mechanisms underlyingHDLI have yet to be conducted. This study aimed to investigate methylation changes and their potential role in HDLI after exposureto HDs containing polyhexamethylene guanidine-phosphate. DNA methylation analysis was performed in blood samplesfrom 10 children with HDLI and 10 healthy children using Infinium Human MethylationEPIC BeadChip. Transcriptome analysiswas performed using lung tissues from 5 children with HDLI and 5 controls. Compared to healthy controls, 92 hypo-methylatedand 79 hyper-methylated CpG sites were identified in children with HDLI at the statistical significance level of |Δβ|>0.2 andp<0.05. NOTCH1 was identified as a candidate network hub gene in cases. NOTCH1 transcripts significantly increased in lung tissuesfrom HDLI cases compared to unexposed controls (p=0.05). NOTCH1 may play an important role in pulmonary fibrosis of HDLI.
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참고문헌 (16)
참고문헌 신청
Kim KW / 2014 / Humidifier disinfectant-associated children’s interstitial lung disease / Am J Respir Crit Care Med 189:48~56
Hong SB / 2014 / A cluster of lung injury associated with home humidifier use : clinical, radiological and pathological description of a new syndrome / Thorax 69:694~702
Ryu SH / 2019 / Humidifier disinfectant and use characteristics associated with lung injury in Korea / Indoor Air 29:735~747
Park DU / 2017 / Types of household humidifier disinfectant and associated risk of lung injury(HDLI)in South Korea / Sci Total Environ
Yoon J / 2017 / Rate of humidifier and humidifier disinfectant usage in Korean children : a nationwide epidemiologic study / Environ Res 155:60~63
Hong SB / 2014 / A cluster of lung injury associated with home humidifier use : clinical, radiological and pathological description of a new syndrome / Thorax 69:694~702
Ryu SH / 2019 / Humidifier disinfectant and use characteristics associated with lung injury in Korea / Indoor Air 29:735~747
Park DU / 2017 / Types of household humidifier disinfectant and associated risk of lung injury(HDLI)in South Korea / Sci Total Environ
Yoon J / 2017 / Rate of humidifier and humidifier disinfectant usage in Korean children : a nationwide epidemiologic study / Environ Res 155:60~63
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