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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 452 - 459 (8page)
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Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) with optimal conditioning has helped better long-term survival in acute lymphoblastic leukemia (ALL). This study investigated the efficacy and safety of reduced-intensity conditioning (RIC) with busulfan and fludarabine in adult ALL patients unfit for myeloablation. Materials and Methods: Records of 78 patients who underwent HSCT with RIC consisting of 3.2 mg/kg/day of busulfan for 2 or 3 days and 30 mg/m2/day of fludarabine for 5 or 6 days were analyzed. Results: The median age at diagnosis was 49 years. Over a median follow-up of 22 months, 2-year estimates of relapse-free survival (RFS) and overall survival were 57.4% and 68.7%, respectively. Multivariate analysis showed a trend of improved RFS in patients with chronic graft-versus-host disease (GVHD) (hazard ratio, 0.53; 95% confidence interval, 0.26–1.08; p=0.080). The cumulative incidences of relapse and non-relapse mortality were 42.9% and 19.6%, respectively and one case of central nervous system relapse was noted. No hepatic veno-occlusive disease was reported. Grade II–IV acute GVHD and any grade chronic GVHD occurred in 21.1% and 41.7%, respectively. Conclusion: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation.
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참고문헌 (19)
참고문헌 신청
Terwilliger T / 2017 / Acute lymphoblastic leukemia : a comprehensive review and 2017 update / Blood Cancer J 7:e577
Marks DI / 2014 / Allogeneic hematopoietic cell transplantation in adult patients with acute lymphoblastic leukemia / Hematol Oncol Clin North Am 28:995~1009
Tavernier E / 2007 / Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial / Leukemia 21:1907~1914
Gyurkocza B / 2014 / Conditioning regimens for hematopoietic cell transplantation : one size does not fit all / Blood 124:344~353
Iravani M / 2007 / Fludarabine and busulfan as a myeloablative conditioning regimen for allogeneic stem cell transplantation in high-and standard-risk leukemic patients / Bone Marrow Transplant 40:105~110
Marks DI / 2014 / Allogeneic hematopoietic cell transplantation in adult patients with acute lymphoblastic leukemia / Hematol Oncol Clin North Am 28:995~1009
Tavernier E / 2007 / Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial / Leukemia 21:1907~1914
Gyurkocza B / 2014 / Conditioning regimens for hematopoietic cell transplantation : one size does not fit all / Blood 124:344~353
Iravani M / 2007 / Fludarabine and busulfan as a myeloablative conditioning regimen for allogeneic stem cell transplantation in high-and standard-risk leukemic patients / Bone Marrow Transplant 40:105~110
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