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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 12 (12page)
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Objectives : The purpose of this study was to identify the anticancer effect of biological substances of ethylacetate(EtOAc) fraction from Orostachys japonicus(OJEF), their effect on human melanoma A375 cells and the related molecular mechanisms. Methods : The MTS assay was used to confirm the inhibition of cancer cell proliferation in A375 cells. And the MUSE™ analyzer was used to determine the ability of OJEF to induce cell cycle arrest. Western blotting was used to determine the changes in protein expression in A375 cells after treatment with OJEF. Results : OJEF showed cytotoxicity to A375 cells. And cell cycle arrest occurred in G1 phase and G2/M phase owing to inhibition of CDK1, cyclin B1, CDK4, and cyclin D, which are related to cell cycle regulation and cell division control. Conclusion : OJEF is effective in regulating cell cycle of human melanoma cells and thus can be a good theraputic agent to treat patients with melanoma.
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참고문헌 (36)
참고문헌 신청
Sekulic A / 2008 / Malignant melanoma in the 21st century : the emerging molecular landscape / Mayo Clinic Proc 83(7):825~846
Rigel DS / 2000 / Malignant melanoma : prevention, early detection, and treatment in the 21st century / CA Cancer J Clin 50(4):215~236
Cho HK / 1999 / Molecular Mechanism of the Antiproliferative Effect by Ginseng Panaxynol on a Human Malignant Melanoma Cell Line, SK-MEL-1 / J Ginseng Res 23(3):190~197
권지혜 / 2017 / 인체 폐암 세포에 대한 와송 유래 에틸아세테이트 분획 생리 활성 물질의 세포사멸 유도 및 세포주기 억제 항암활성 / 예술인문사회 융합 멀티미디어 논문지 7(1):395~405
이봉무 / 2013 / 안면부에 발생한 기저세포암 137례의 임상적 고찰 / Archives of Craniofacial Surgery 14(2):107~110
Rigel DS / 2000 / Malignant melanoma : prevention, early detection, and treatment in the 21st century / CA Cancer J Clin 50(4):215~236
Cho HK / 1999 / Molecular Mechanism of the Antiproliferative Effect by Ginseng Panaxynol on a Human Malignant Melanoma Cell Line, SK-MEL-1 / J Ginseng Res 23(3):190~197
권지혜 / 2017 / 인체 폐암 세포에 대한 와송 유래 에틸아세테이트 분획 생리 활성 물질의 세포사멸 유도 및 세포주기 억제 항암활성 / 예술인문사회 융합 멀티미디어 논문지 7(1):395~405
이봉무 / 2013 / 안면부에 발생한 기저세포암 137례의 임상적 고찰 / Archives of Craniofacial Surgery 14(2):107~110
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