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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 127 - 134 (8page)
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ObjectiveaaBiological markers for Alzheimer’s disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than the onset of clinical manifestations in AD.
MethodsaaWe examined the lymphocyte expression of cell cycle proteins in AD patients, dementia controls (DC), and normal controls (NC). One-hundred seventeen subjects (36 AD, 31 DC, and 50 NC) were recruited. The cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were measured in peripheral lymphocytes. Cell cycle protein expression in the three groups was compared after adjusting for age and sex.
ResultsaaThe levels of cell cycle proteins CDK2, CDK4, CDK6, cyclin B, and cyclin D were significantly higher in AD patients than in the NC subjects. The DC group manifested intermediate levels of cell cycle proteins compared with the AD patients and the NC subjects. The present study indicates that cell cycle proteins are upregulated in the peripheral lymphocytes of AD patients.
ConclusionaaCell cycle dysregulation in peripheral lymphocytes may present a promising starting point for identifying peripheral biomarkers of AD.
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참고문헌 (41)
참고문헌 신청
Busser J / 1998 / Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer’s disease brain / J Neurosci 18:2801~2807
McShea A / 2007 / Neuronal cell cycle re-entry mediates Alzheimer disease-type changes / Biochim Biophys Acta 1772:467~472
Nuydens R / 1998 / Okadaic acid-induced apoptosis in neuronal cells : evidence for an abortive mitotic attempt / J Neurochem 70:1124~1133
Raina AK / 2000 / Cyclin’ toward dementia : cell cycle abnormalities and abortive oncogenesis in Alzheimer disease / J Neurosci Res 61:128~133
Vincent I / 1997 / Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer’s disease brain / J Neurosci 17:3588~3598
McShea A / 2007 / Neuronal cell cycle re-entry mediates Alzheimer disease-type changes / Biochim Biophys Acta 1772:467~472
Nuydens R / 1998 / Okadaic acid-induced apoptosis in neuronal cells : evidence for an abortive mitotic attempt / J Neurochem 70:1124~1133
Raina AK / 2000 / Cyclin’ toward dementia : cell cycle abnormalities and abortive oncogenesis in Alzheimer disease / J Neurosci Res 61:128~133
Vincent I / 1997 / Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer’s disease brain / J Neurosci 17:3588~3598
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