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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제2호
- 발행연도
- 2020.1
- 수록면
- 95 - 99 (5page)
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초록· 키워드
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Canine inflammatory mammary carcinoma (CIMC) similar to human inflammatory breast cancer is a very aggressive, metastatic type of cancer. Previous studies have introduced a new type of tumor angiogenesis called vasculogenic mimicry that may play an important role in the progression of inflammatory mammary cancer. The purpose of this study is to investigate the development process of vessels by neoplastic cells in CIMC. Patient dog, 14-year old Shit-Tzu female, had a hard and somewhat movable dark-reddish mammary tumor, sized 6.2 cm in diameter. Bloody dark turbid exudate was released from the tumor. In addition to histological examination, immunohistochemistry for pancytokeratin, VCAM-1, MECA- 32, TWIST-1, and Ki-67 was respectively performed using the ABC method. Histologically, the inflammatory mammary carcinoma was characterized by tubular solid tumor emboli within the lymphatic vessels surrounded by desmoplastic fibrous connective tissue. Some of the neoplastic cells were transforming into elongate or spindle shapes and forming small vessel-like structures in the solid tumor mass. The neoplastic cells were immunoreactive for VCAM-1 and MECA-32, but showed low immunoreactivity for Ki-67. Immunoreactive neoplastic cells for VCAM-1 and MECA-32 suggested the possibility that the neoplastic cells transform into endothelial cells of vessels by epithelial-mesenchymal transition, further supported by serial morphological changes identified by histological investigation and immunohistochemistry for TWIST-1. The high capacity of the neoplastic cells forming the vasculatures in CIMC explains the high ratio of metastasis to other regions, even though Ki-67 index was not so high.
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참고문헌 (24)
참고문헌 신청
Alenza MDP / 2001 / Inflammatory mammary carcinoma in dogs : 33 cases(1995–1999) / J Am Vet Med Assoc 219:1110~1114
Camacho L / 2013 / Establishment and characterization of a canine xenograft model of inflammatory mammary carcinoma / Res Vet Sci 95:1068~1075
Camacho L / 2014 / Immunohistochemical vascular factor expression in canine inflammatory mammary carcinoma / Vet Pathol 51:737~748
Kim JH / 2011 / Inflammatory mammary carcinoma with metastasis to the brain and distant organs in a spayed Shih Tzu dog / J Vet Diag Invest 23:1079~1082
Clemente M / 2010 / Histological, immunohistological, and ultrastructural description of vasculogenic mimicry in canine mammary cancer / Vet Pathol 47:265~274
Camacho L / 2013 / Establishment and characterization of a canine xenograft model of inflammatory mammary carcinoma / Res Vet Sci 95:1068~1075
Camacho L / 2014 / Immunohistochemical vascular factor expression in canine inflammatory mammary carcinoma / Vet Pathol 51:737~748
Kim JH / 2011 / Inflammatory mammary carcinoma with metastasis to the brain and distant organs in a spayed Shih Tzu dog / J Vet Diag Invest 23:1079~1082
Clemente M / 2010 / Histological, immunohistological, and ultrastructural description of vasculogenic mimicry in canine mammary cancer / Vet Pathol 47:265~274
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