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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Canine mammary tumors account for ~30% of all tumors in the female dogs and approximately 50% of the tumors are malignant. Exosomes have been the focus of great interest, as they appear to be involved in numerous important cellular processes. In this study, we examined the anti-tumor effects of canine mesenchymal stem cells-derived exosomes (MSC-exosomes) in an experimental murine mammary tumor model using canine mammary carcinoma cells, REM134. The MSC-exosomes were injected tumor site and tail vein of REM134 xenografted mice. We found that tumor size of the MSC-exosomes-treated group decreased compared to those of the only tumor group in REM134-driven tumorigenic mouse model. In addition, the MSC-exosomes-treated tumor group showed meaningfully reduced expression levels of the MMP-3, IL-1β, IL-6, and TNF-α compared to those in the tumor group. Specifically, we confirmed that the expression level of the CD133, potent cancer stem cell (CSC) markers, decreased in the MSC-exosomes-treated tumor group compared to the tumor group. This study suggests that the MSC-exosomes exhibited anti-tumor effects through downregulating CSC-related markers in the canine mammary tumor murine model. Further study is needed in the future, and we are conducting research on the detailed anti-tumor mechanism of the MSC-exosomes.
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참고문헌 (32)
참고문헌 신청
Addissie S / 2018 / Cellular immunotherapy of canine cancer / Vet Sci 5:100
Arslan F / 2013 / Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury / Stem Cell Res 10:301~312
Brick JO / 1968 / Chemotherapy of malignant lymphoma in dogs and cats / J Am Vet Med Assoc 153:47~52
Crain SK / 2019 / Extracellular vesicles from Wharton's jelly mesenchymal stem cells suppress CD4 expressing T cells through transforming growth factor beta and adenosine signaling in a canine model / Stem Cells Dev 28:212~226
Deryugina EI / 2006 / Matrix metalloproteinases and tumor metastasis / Cancer Metastasis Rev 25:9~34
Arslan F / 2013 / Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury / Stem Cell Res 10:301~312
Brick JO / 1968 / Chemotherapy of malignant lymphoma in dogs and cats / J Am Vet Med Assoc 153:47~52
Crain SK / 2019 / Extracellular vesicles from Wharton's jelly mesenchymal stem cells suppress CD4 expressing T cells through transforming growth factor beta and adenosine signaling in a canine model / Stem Cells Dev 28:212~226
Deryugina EI / 2006 / Matrix metalloproteinases and tumor metastasis / Cancer Metastasis Rev 25:9~34
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