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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 243 - 254 (12page)
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Vascular complications from uncontrolled hyperglycemia are the leading cause of death in patients with diabetes mellitus. Previous reports have shown a strong correlation between hyperglycemia and vascular calcification, which increases mortality and morbidity in individuals with diabetes. However, the precise underlying molecular mechanisms of hyperglycemia-induced vascular calcification remain largely unknown. Transdifferentiation of vascular smooth muscle cells (VSMC) into osteoblast-like cells is a known culprit underlying the development of vascular calcification in the diabetic vasculature. Pathological conditions such as high glucose levels and oxidative stress are linked to enhanced osteogenic differentiation of VSMC both in vivo and in vitro. It has been demonstrated that increased expression of runt-related transcription factor 2 (Runx2), a bone-related transcription factor, in VSMC is necessary and sufficient for the induction of VSMC calcification. Addition of a single O-linked β-N-acetylglucosamine (O-GlcNAc) moiety to the serine/threonine residues of target proteins (O-GlcNAcylation) has been observed in the arteries of diabetic patients, as well as in animal models in association with the enhanced expression of Runx2 and aggravated vascular calcification. O-GlcNAcylation is a dynamic and tightly regulated process, that is mediated by 2 enzymes, O-GlcNAc transferase and O-GlcNAcase. Glucose is metabolized into UDP-β-D-N-acetylglucosamine, an active sugar donor of O-GlcNAcylation via the hexosamine biosynthetic pathway. Overall increases in the O-GlcNAcylation of cellular proteins have been closely associated with cardiovascular complications of diabetes. In this review, the authors provide molecular insights into cardiovascular complications, including diabetic vasculopathy, that feature increased O-GlcNAcylation in people with diabetes.
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참고문헌 (81)
참고문헌 신청
International Diabetes Federation / 2019 / IDF diabetes atlas / International Diabetes Federation
Badimon L / 2014 / Thrombosis formation on atherosclerotic lesions and plaque rupture / J Intern Med 276:618~632
Lacolley P / 2017 / Vascular smooth muscle cells and arterial stiffening : relevance in development, aging, and disease / Physiol Rev 97:1555~1617
Boström KI / 2011 / The regulation of valvular and vascular sclerosis by osteogenic morphogens / Circ Res 109:564~577
Chen NX / 2003 / Arterial calcification in diabetes / Curr Diab Rep 3:28~32
Badimon L / 2014 / Thrombosis formation on atherosclerotic lesions and plaque rupture / J Intern Med 276:618~632
Lacolley P / 2017 / Vascular smooth muscle cells and arterial stiffening : relevance in development, aging, and disease / Physiol Rev 97:1555~1617
Boström KI / 2011 / The regulation of valvular and vascular sclerosis by osteogenic morphogens / Circ Res 109:564~577
Chen NX / 2003 / Arterial calcification in diabetes / Curr Diab Rep 3:28~32
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