Association between the MUC1 rs4072037 Polymorphism and Risk of Gastric Cancer and Clinical Outcomes

Kyuyoung Song; 김범수; Inchul Lee; 육정환; 김병식

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자료유형: 학술저널

저자정보: Kyuyoung Song 김범수 Inchul Lee 육정환 김병식

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제20권 제2호

발행연도: 2020.1

수록면: 127 - 138 (12page)

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Purpose: Mucin 1 (MUC1) was identified as a gastric cancer (GC) susceptibility gene by genome-wide association studies in Asians and candidate gene studies in Europeans. This study aimed to investigate the association between the MUC1 rs4072037 polymorphism and GC in terms of the Lauren classification and long-term clinical outcomes. Materials and Methods: A total of 803 patients with GC and 816 unrelated healthy controls were enrolled in the study. The association between the MUC1 rs4072037 variant and GC histological types and clinical outcomes, including tumor recurrence and prognosis was investigated. Results: The major A allele of rs4072037 was associated with increased GC risk (P<0.05). In subtype analysis, the association was most significant for diffuse-type GC (P<0.05) and in a dominant model (P<0.05), whereas there was no association with intestinal-type GC (P>0.05). Cox proportional hazards analysis revealed the heterozygote AG rs4072037 allele as an independent risk factor influencing tumor recurrence and disease-related death in diffuse-type GC (P<0.05). but not in intestinal-type GC (P>0.05). Conclusions: The exonic single nucleotide polymorphism rs4072037 in MUC1 was associated with diffuse-type GC and was an independent risk factor influencing tumor recurrence and disease-related death in diffuse-type GC.

참고문헌 (23)

참고문헌 신청

World Health Organization / WHO fact sheets: cancer

Shi Y / 2011 / A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13. 31 and 5p13. 1 / Nat Genet 43:1215~1218

Lauren P / 1965 / The two histological main types of gastric carcinoma : diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification / Acta Pathol Microbiol Scand 64:31~49

Chiba T / 2008 / Mechanism for gastric cancer development by Helicobacter pylori infection / J Gastroenterol Hepatol 23:1175~1181

Schier S / 2005 / Stem cell relationships and the origin of gastrointestinal cancer / Oncology 69(Suppl 1):9~13

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