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자료유형
학술저널
저자정보
저널정보
대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제19권 제3호
발행연도
2019.1
수록면
235 - 253 (19page)

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Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinicaltreatment decisions are mostly made based on the extent of the tumor and its anatomy,such as tumor-node-metastasis staging. Recent advances in genome-wide moleculartechnology have enabled delineation of the molecular characteristics of GC. Based on this,efforts have been made to classify GC into molecular subtypes with distinct prognosis andtherapeutic response. Simplified algorithms based on protein and RNA expressions havebeen proposed to reproduce the GC classification in the clinical field. Furthermore, a recentstudy established a single patient classifier (SPC) predicting the prognosis and chemotherapyresponse of resectable GC patients based on a 4-gene real-time polymerase chain reactionassay. GC patient stratification according to SPC will enable personalized therapeuticstrategies in adjuvant settings. At the same time, patient-derived xenografts and patientderivedorganoids are now emerging as novel preclinical models for the treatment of GC. These models recapitulate the complex features of the primary tumor, which is expected tofacilitate both drug development and clinical therapeutic decision making. An integratedapproach applying molecular patient stratification and patient-derived models in the clinicalrealm is considered a turning point in precision medicine in GC.

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