지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.2
- 발행연도
- 2020.8
- 수록면
- 97 - 109 (13page)
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초록· 키워드
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Purpose: The role of adjuvant chemotherapy for patients with ypT0–2N0 rectal cancer following neoadjuvant chemoradiotherapy (nCRT) and curative surgery is uncertain. We performed a meta-analysis using selected studies to compare adjuvant chemotherapy with observation for this cohort of patients.
Methods: PubMed, Embase, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random effect models. Outcome measures were 5-year overall survival (OS), disease-free survival (DFS), local, and distant recurrence.
Results: We included 17 nonrandomized studies for qualitative analysis and 16 nonrandomized studies that examined 4,747 patients for the meta-analysis. In analysis of patients with ypT0N0 rectal cancer, adjuvant chemotherapy had no significant effect on OS (odds ratio [OR], 1.53; 95% confidence interval [CI], 0.86–2.72; I² = 27%), DFS (OR, 1.22; 95% CI, 0.61–2.42; I² = 5%), local recurrence (OR, 0.78; 95% CI, 0.08–7.37; I² = 0%), and distant recurrence (OR, 1.04; 95% CI, 0.41–2.62; I² = 0%). In analysis of patients with ypT1–2N0 rectal cancer, adjuvant chemotherapy also had no significant effect on OS (OR, 2.15; 95% CI, 0.59–7.80; I² = 26%), DFS (OR, 1.66; 95% CI, 0.35–7.85; I² = 44%), local recurrence (OR, 2.56; 95% CI, 0.72–9.13; I² = 0%), and distant recurrence (OR, 1.15; 95% CI, 0.23–5.87; I² = 0%).
Conclusion: Adjuvant chemotherapy may have no oncologic benefits in patients with ypT0–2N0 rectal cancer after nCRT and radical surgery. Routine use of adjuvant chemotherapy for those patients may be avoided.
Methods: PubMed, Embase, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random effect models. Outcome measures were 5-year overall survival (OS), disease-free survival (DFS), local, and distant recurrence.
Results: We included 17 nonrandomized studies for qualitative analysis and 16 nonrandomized studies that examined 4,747 patients for the meta-analysis. In analysis of patients with ypT0N0 rectal cancer, adjuvant chemotherapy had no significant effect on OS (odds ratio [OR], 1.53; 95% confidence interval [CI], 0.86–2.72; I² = 27%), DFS (OR, 1.22; 95% CI, 0.61–2.42; I² = 5%), local recurrence (OR, 0.78; 95% CI, 0.08–7.37; I² = 0%), and distant recurrence (OR, 1.04; 95% CI, 0.41–2.62; I² = 0%). In analysis of patients with ypT1–2N0 rectal cancer, adjuvant chemotherapy also had no significant effect on OS (OR, 2.15; 95% CI, 0.59–7.80; I² = 26%), DFS (OR, 1.66; 95% CI, 0.35–7.85; I² = 44%), local recurrence (OR, 2.56; 95% CI, 0.72–9.13; I² = 0%), and distant recurrence (OR, 1.15; 95% CI, 0.23–5.87; I² = 0%).
Conclusion: Adjuvant chemotherapy may have no oncologic benefits in patients with ypT0–2N0 rectal cancer after nCRT and radical surgery. Routine use of adjuvant chemotherapy for those patients may be avoided.
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INTRODUCTION
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UCI(KEPA) : I410-ECN-0101-2020-514-001100162