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논문 기본 정보

자료유형
학술대회자료
저자정보
Youm, Jong-kyung (NeoPharm Co. Ltd, Research center, BVC-307, KRIBB) Kim, Yang-hee (NeoPharm Co. Ltd, Research center, BVC-307, KRIB) Park, Byeong-deog (NeoPharm Co. Ltd, Research center, BVC-307, KRIB) Jeong, Se-kyoo (Central Research Laboratories, Aekyung Co. Lt) Park, Eung-ho (Department of Dermatology, Wonju University, College of Medicin) Ahn, Sung-ku (Department of Dermatology, Wonju University, College of Medicin) Lee, Seung-hun (BK21 Project for Medical Science, Yonsei University, College of Medicine)
저널정보
대한화장품학회 대한화장품학회 학술대회 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
발행연도
2003.1
수록면
765 - 779 (15page)

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Physiological lipid mixtures comprised of cholesterol, ceramide and free fatty acid better maintain epidermal homeostasis and have been recently used for dermatoses induced by skin barrier damage, for example for atopic dermatitis and xerotic skin. Itching and dry atopic dermatitis of the skin may be related to altered skin barrier function. In a previous study, the use of multi-lamellar emulsion (MLE), which is a lipid mixtures containing cholesterol, pseudoceramide and free fatty acid, has been shown to accelerate the recovery of the epidermal permeability barrier. In this study, we assessed the efficacy of MLE compared with a currently used anti-itch moisturizer (AIM), the active ingredients of which are menthol and camphor, on barrier recovery after barrier disruption. To clarify the effect of MLE and AIM after acute barrier perturbation, we measured the relation between transepidermal water loss (TEWL) and the barrier recovery rate at 3, 6, 24, and 48 hours after tape stripping hairless mice and then observed changes in the stratum corneum (SC), including the intercellular lipid structure and secretion of lamellar bodies, by electron microscopy. MLE treated skin recover skin barrier function more rapidly, and AIM treated skin delayed barrier repair. Morphological changes in the epidermis, of MLE treated skin revealed well-conserved lipid multi-lamellar structures at 24 h after tape stripping, whereas AIM treated skin showed altered lamellar bilayers within the SC interstices at 48 h. In addition, MLE treated skin showed an increase in the number of LBs and in their secretions and a decrease in the number of SC layers versus AIM treated skin. These results suggest that MLE may accelerate the production of an epidermal permeability barrier in hairless mice by increasing the number and secretion of LB and improve the dryness and itch associated with an altered epidermal permeability barrier.

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