지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2001.1
- 수록면
- 109 - 109 (1page)
이용수
초록· 키워드
오류제보하기
The present study was done to investigate the relationship between Kupffer cells and alteration of cytochrome P-450 (CYP)-dependent drug metabolizing enzyme activities during polymicrobial sepsis. Male rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP) followed by fluid resuscitation. The gadolinium chloride (GdC1$_3$, 10 mg/kg), blocker of Kupffer cells, was pretreated intravenously at 48 h and 24 h prior to the induction of CLP. All assay parameters were determined at 24 h after CLP or sham operation. In CLP-treated rats, the mortality rate of animals increased to 50% and serum alanine (ALT) and aspartate aminotransferase (AST) levels also significantly elevated. However, this increase was not suppressed by GdC1$_3$ pretreatment. Microsomal lipid peroxidation markedly increased after CLP operation. This increase was significantly attenuated by pretreatment. Total cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity were not changed after CLP operation, but GdC1$_3$pretreatment reduced total cytochrome P-450 content, The hepatic microsomal CYP 1A1, 1A2, 2Bl and 2El activities in CLP-induced rats were also not significantly different from sham-operated rats. However, GdC1$_3$pretreatment showed a moderate increase in CYP1A1 and 1A2 activities. Our findings suggest that Kupffer cells may be partly responsible for producing hepatocellular dysfunction during sepsis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis
대한약학회 학술대회
2002 .01
-
Kupffer Cells Are Responsible for Producing Hepatic Microsomal Drug Metabolizing Dysfunction during Trauma and Sepsis
대한약학회 학술대회
2002 .01
-
The Beneficial Effect of Trolox on Sepsis-Induced Hepatic Drug Metabolizing Dysfunction
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Effect of a-Tocopherol on Vasoregulatory Gene Expression during Polymicrobial Sepsis
한국응용약물학회 추계학술발표논문집
2003 .01
-
패혈증에서 Heat Shock Protein 70의 과도발현이 Inducible Nitric Oxide Synthase의 발현에 미치는 효과
Journal of trauma and injury : JTI
2008 .01
-
The Roles of Kupffer Cells in Hepatocellular Dysfunction after Femur Fracture Trauma in Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
백서의 패혈증 모델에서 시간에 따른 폐조직에서의 Inducible Nitric Oxide Synthase 발현
Journal of trauma and injury : JTI
2008 .01
-
치관 길이 확장술(CLP)
대한치과의사협회지
1997 .07
-
Spectral & Aerodynamic Analysis of Cries in Infants with Cleft Lip and Palate.
대한구순구개열학회지
2002 .01
-
Alteration of Hepatic Drug Metabolizing Function after Traumatic Injury
대한약학회 학술대회
2002 .01
-
물질안전보건자료 및 표시제도의 개선 방향 제안(2) - 유럽연합의 CLP 제도 고찰에 근거하여
한국산업보건학회지
2015 .01
-
흰쥐에서 Kupffer 세포가 간 재생에 미치는 영향
Annals of Surgical Treatment and Research
1991 .11
-
The Roles of Kupffer Cells in Hepatic Dysfunction Induced by Ischemia/Reperfusion in Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Effect of Ascorbic Acid on the Activity and Gene Expression of Cytochrome P450 in Sepsis
대한약학회 학술대회
2003 .01
-
Identification of CLP36 as a Tumor Antigen that Induces an Antibody Response in Pancreatic Cancer
Cancer Research and Treatment
2005 .01
-
인삼이 백서 간 약물대사효소에 미치는 효과
약학회지
1981 .01
-
Ventilation accelerates lung injury in septic mice
Journal of Biomedical and Translational Research
2019 .01
-
Long-Term Outcome of Cystic Lesions in the Pancreas: A Retrospective Cohort Study
Gut and Liver
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0