지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제2호
- 발행연도
- 2004.1
- 수록면
- 232 - 238 (7page)
이용수
초록· 키워드
오류제보하기
Trolox is a hydrophilic analogue of vitamin E. The aim of this study was to investigate its effects on hepatic injury, especially alteration in cytochrome P450 (CYP)-dependent drug metabolism during polymicrobial sepsis. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP). The rats were treated intravenously with Trolox (2.5 mg/kg) or vehicle, immediately after CLP. Serum aminotransferases and lipid peroxidation levels were markedly increased 24 h after CLP. This increase was attenuated by Trolox. Total CYP content and NADPH-P450 reductase activity decreased significantly 24 h after CLP. This decrease in CYP content was attenuated by Trolox. At 24 h after CLP, there was a significant decrease in the activity of these CYP isozymes: CYP1A1, 1A2, 2B1, and 2E1. However, Trolox differentially inhibited the decrease in CYP isozyme activity. Trolox had little effect on the decrease in CYP1A1 activity but Trolox significantly attenuated decreases in CYP1A2 and 2E1 activities. In fact, Trolox restored CYP2B1 activity to the level of activity found in control rats. Our findings suggest that Trolox reduces hepatocellular damage as indicated by abnormalities in hepatic drug-metabolizing function during sepsis. Our data also indicates that this protection is, in part, caused by decreased lipid peroxidation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Trolox C Ameliorates Hepatic Drug Metabolizing Dysfunction After Ischemia/Reperfusion
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Effect of Trolox C on CYP450 Isozymes Activity and Expression in Hepatic Ischemia/Reperfusion
대한약학회 학술대회
2002 .01
-
Effect of Trolox on Altered Vasoregulatory Gene Expression in Hepatic Ischemia/Reperfusion
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Role of Kupffer Cells in Hepatic Drug Metabolizing Functions during Sepsis in Rats
한국응용약물학회 추계학술발표논문집
2001 .01
-
Effect of Trolox C in the Vasoregulatory Gene Expression during Hepatic Ischemia/Reperfusion
대한약학회 학술대회
2003 .01
-
Effect of Trolox C on Hypoxia/Reoxygenation-Induced Injury in Isolated Perfused Rat Liver
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes
대한한의학회지
2014 .06
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
-
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Toxicological Research
2011 .03
-
Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis
대한약학회 학술대회
2002 .01
-
CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
대한약학회 학술대회
2002 .01
-
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
-
CYP2E1과 CYP2C19 유전자 다형성이 위암 발생 감수성에 미치는 영향
Annals of Surgical Treatment and Research
2007 .08
-
Effect of Ascorbic Acid on the Activity and Gene Expression of Cytochrome P450 in Sepsis
대한약학회 학술대회
2003 .01
-
Xylene에 의한 CYP2B1/2의 유도와 대사에 있어서 toluene의 영향
한국산업보건학회지
2009 .01
-
Effects of Water Deprivation on Drug Pharmacokinetics: Correlation between Drug Metabolism and Hepatic CYP Isozymes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
생물정신의학
2000 .01
-
약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
대한한의학회지
2007 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0